79844-16-9Relevant academic research and scientific papers
Thiazolidin-4-one, azetidin-2-one and 1,3,4-oxadiazole derivatives of isonicotinic acid hydrazide: Synthesis and their biological evaluation
Gilani, Sadaf J.,Khan, Suroor A.,Alam, Ozair,Singh, Vijender,Arora, Alka
, p. 1057 - 1067 (2012/02/05)
A series of thiazolidin-4-one (2a-h; 3a-h), azetidin-2-one (4a-h) and 1,3,4-oxadiazole (5a-h) derivatives of isoninicotinic acid hydrazide (INH) were synthesized in order to obtain new compounds with potential anti-inflammatory, analgesic, ulcerogenic and
Synthesis and antimicrobial activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide
Thomas, Asha B.,Nanda, Rabindra K.,Kothapalli, Lata P.,Deshpande, Avinash D.
scheme or table, p. 960 - 968 (2012/03/08)
A series of isonicotinyl hydrazones and their 4-thiazolidinones have been synthesized by condensation of isonicotinic acid hydrazide with various aromatic aldehydes to yield Schiff's bases, followed by the cyclocondensation of Schiff's bases with 2-mercaptoacetic acid to yield their 4-thiazolidinones. The synthesized compounds have been characterized by their elemental, analytical and spectral studies. All these compounds were evaluated for their invitro antimicrobial activity against a spectrum of non-resistant and resistant microbial organisms. These studies proved that compounds 5e,i against B. subtilis; 5e,f,h against B. anthracis; 5g,i against S. aureus showed good activity at lower concentrations. Compounds 5d-5i displayed significant activity against resistant strain of K. pneumonia with minimum inhibitory potency in the concentration range of 2-16 ug/ml.
Synthesis and antimicrobial activity of 5-amino-2,7-diaryl-6-cyano-3- isonicotinamido thiazolo[4,5-b]-2,3,4,7-tetrahydropyridines, 2,7-diaryl-6-cyano-3-isonicotinamidothiazolo[4,5-b]-2,3,4,5,6, 7-hexahydropyrid-5-ones, 2,7-diaryl-5-amino-3-isonicotinamido
Khan, Mukhtar Hussain
, p. 148 - 153 (2008/02/09)
5-Amino-2,7-diaryl-6-cyano-3-isonicotinamido thiazolo[4,5-b]-2,3,4,7- tetrahydropyridines 3 and 2,7-diaryI-6-cyano-3-isonicotinamido thiazolo[4,5-b]-2,3,4,5,6,7-hexahydropyrid-5-ones 4 have been prepared by Michael addition between α,βunsaturated ketones
