798565-60-3

Upstream product

• 96729-80-5 2-(3,4-dimethoxyphenyl)-3-oxopropanenitrile 
• 18029-60-2 6,7-dimethoxy-1-oxo-1,2-dihydroisoquinoline-4-carbonitrile 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 798565-62-5 1-(3-ethoxy-benzoyl)-6,7-dimethoxy-isoquinoline-4-carbonitrile 
• 798565-45-4 1-bromo-6,7-dimethoxyisoquinoline-4-carbonitrile 
• 18029-59-9 ethyl (2-cyano-2-(3,4-dimethoxyphenyl)vinyl)carbamate 

Relevant academic research and scientific papers

Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors

Through high throughput screening and subsequent hit identification and optimization, we synthesized a series of 1-arylcarbonyl-6,7- dimethoxyisoquinoline derivatives as the first reported potent and reversible GFAT inhibitors. SAR studies of this class o

GFAT INHIBITORS

Compounds of formula (I) are provided as well as pharmaceutically acceptable salts and esters thereof, wherein the substituents are as disclosed in the specification. The compounds have utility for the treatment of type 2 diabetes mellitus.