79868-19-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-N,N-diethylbenzamide is used as a reagent in the synthesis of proline-rich tyrosine kinase (Pyk2) and focal adhesion kinase (FAK) inhibitors. These inhibitors are important for the development of drugs targeting various diseases, including cancer and inflammatory disorders. Pyk2 and FAK are non-receptor protein tyrosine kinases that play crucial roles in cell signaling pathways involved in cell proliferation, migration, and survival.
In the synthesis of Pyk2 and FAK inhibitors, 4-Amino-N,N-diethylbenzamide serves as a key intermediate, providing a versatile platform for the development of novel and potent inhibitors. By incorporating 4-AMINO-N,N-DIETHYLBENZAMIDE into the molecular structure of the inhibitors, researchers can explore its potential to modulate the activity of these kinases, leading to the discovery of new therapeutic agents.
Furthermore, 4-Amino-N,N-diethylbenzamide may also be used in the development of other biologically active molecules with potential applications in various industries, such as agriculture, where it could be employed as a pesticide or herbicide, or in the chemical industry for the synthesis of other organic compounds.

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 142-84-7 di-n-propylamine 
• 79868-22-7 4-nitro-N,N-(di-n-propyl)benzamide 

Relevant academic research and scientific papers

Anticonvulsant activity of some 4-aminobenzamides

A series of 4-aminobenzamides of some simple primary and secondary amines were prepared and evaluated for anticonvulsant effects. The compounds were tested in mice against seizures induced by electroshock and pentylenetetrazole (metrazole) and in the rotorod assay for neurologic deficit. For those N-alkyl amides tested, 4-amino-N-amylbenzamide was the most potent against maximal electroshock seizures (MES): ED50=42.98 mg/kg; however, the N-cyclohexylbenzamide showed the greatest protective index (PI=TD50/ED50), 2.8. The introduction of a second aromatic ring produced more potent compounds, with d,l-4-amino-N-(α-methylbenzyl)-benzamide showing the highest level of activity. This compound has an anti-MES ED50 of 18.02 mg/kg in mice when administered intraperitoneally (ip) and a TD50 of 170.78 mg/kg (PI=9.5) in the same species. These data compare quite favorably with those for phenobarbital and phenytoin in the same assays.

Method of suppressing body odor with aminobenzoic acid amides

This invention is directed to a cosmetic deodorant composition comprising: (a) from about 0.1 to 5 percent by weight, based on the weight of the total composition, of aminobenzoic acid amides of the formula STR1 wherein R1 and R2, which may be the same or different, each represent hydrogen, an alkyl of from 1 to 12 carbon atoms; a hydroxyalkyl of from 2 to 4 carbon atoms; an aryl; an aralkyl or carboxyalkyl with from 1 to 3 carbon atoms in the alkyl moiety; or an alkoxyalkyl with from 1 to 8 carbon atoms in the alkoxy moiety and from 1 to 3 carbon atoms in the alkyl moiety, or R1 and R2 together with the amide nitrogen form an optionally substituted heterocyclic ring; and (b) the remainder conventional cosmetic deodorant composition compounds.

Anti-convulsant

New amino-benzamides and their use for the treatment of epilepsy.