79868-22-7

Usage

Uses

Used in Research and Development:
4-nitro-N,N-dipropylbenzamide is used as a building block in the synthesis of various chemicals and pharmaceutical compounds, contributing to the advancement of scientific knowledge and the creation of novel products.
Used in Organic Synthesis:
In the field of organic synthesis, 4-nitro-N,N-dipropylbenzamide is employed as an intermediate, facilitating the production of complex organic molecules and contributing to the development of new chemical entities.
Used in Pharmaceutical Development:
4-nitro-N,N-dipropylbenzamide may have potential applications in the pharmaceutical industry as an intermediate in the development of new drug candidates, potentially leading to the discovery of innovative treatments and therapies.

Upstream product

• 142-84-7 di-n-propylamine 
• 62-23-7 4-nitro-benzoic acid 
• 555-16-8 4-nitrobenzaldehdye 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 79868-19-2 4-amino-N,N-(di-n-propyl)-benzamide 

Relevant academic research and scientific papers

Poly(methylhydrosiloxane) as a green reducing agent in organophosphorus-catalysed amide bond formation

Development of catalytic amide bond formation reactions has been the subject of the intensive investigations in the past decade. Herein we report an efficient organophosphorus-catalysed amidation reaction between unactivated carboxylic acids and amines. Poly(methylhydrosiloxane), a waste product of the silicon industry, is used as an inexpensive and green reducing agent for in situ reduction of phosphine oxide to phosphine. The reported method enables the synthesis of a wide range of secondary and tertiary amides in very good to excellent yields.

Catalyst-free amidation of aldehyde with amine under mild conditions

A highly efficient, catalyst-free and one-pot procedure for the direct synthesis of amides from aldehydes and amines under mild conditions has been developed. Both aliphatic and aromatic aldehydes with primary or secondary amines are successfully converted to the corresponding amides, and it is observed that reactions can proceed in either aqueous or organic media.

Method of suppressing body odor with aminobenzoic acid amides

This invention is directed to a cosmetic deodorant composition comprising: (a) from about 0.1 to 5 percent by weight, based on the weight of the total composition, of aminobenzoic acid amides of the formula STR1 wherein R1 and R2, which may be the same or different, each represent hydrogen, an alkyl of from 1 to 12 carbon atoms; a hydroxyalkyl of from 2 to 4 carbon atoms; an aryl; an aralkyl or carboxyalkyl with from 1 to 3 carbon atoms in the alkyl moiety; or an alkoxyalkyl with from 1 to 8 carbon atoms in the alkoxy moiety and from 1 to 3 carbon atoms in the alkyl moiety, or R1 and R2 together with the amide nitrogen form an optionally substituted heterocyclic ring; and (b) the remainder conventional cosmetic deodorant composition compounds.

Anticonvulsant activity of some 4-aminobenzamides

A series of 4-aminobenzamides of some simple primary and secondary amines were prepared and evaluated for anticonvulsant effects. The compounds were tested in mice against seizures induced by electroshock and pentylenetetrazole (metrazole) and in the rotorod assay for neurologic deficit. For those N-alkyl amides tested, 4-amino-N-amylbenzamide was the most potent against maximal electroshock seizures (MES): ED50=42.98 mg/kg; however, the N-cyclohexylbenzamide showed the greatest protective index (PI=TD50/ED50), 2.8. The introduction of a second aromatic ring produced more potent compounds, with d,l-4-amino-N-(α-methylbenzyl)-benzamide showing the highest level of activity. This compound has an anti-MES ED50 of 18.02 mg/kg in mice when administered intraperitoneally (ip) and a TD50 of 170.78 mg/kg (PI=9.5) in the same species. These data compare quite favorably with those for phenobarbital and phenytoin in the same assays.