79868-79-4

Basic information

• Product Name: Benzeneethanol, b-amino-a,a-diphenyl-, (bR)-
• Synonyms: Benzeneethanol,b-amino-a,a-diphenyl-, (R)-;(2R)-2-Amino-1,1,2-triphenylethanol;(R)-(+)-1,1,2-Triphenyl-2-aminoethanol;(R)-2-Amino-1,1,2-triphenylethanol
• CAS NO: 79868-79-4
• Molecular Formula: C₂₀H₁₉NO
• Molecular Weight: 289.371
• Mol File: 79868-79-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 130-131℃
• Boiling Point: 456 °C at 760 mmHg
• Flash Point: 229.6 °C
• Appearance: /
• Density: 1.162 g/cm³
• Vapor Pressure: 4.17E-09mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.89±0.50(Predicted)
• CAS DataBase Reference: Benzeneethanol, b-amino-a,a-diphenyl-, (bR)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanol, b-amino-a,a-diphenyl-, (bR)-(79868-79-4)
• EPA Substance Registry System: Benzeneethanol, b-amino-a,a-diphenyl-, (bR)-(79868-79-4)

Safety Data

• Hazardous Substances Data: 79868-79-4(Hazardous Substances Data)

Usage

General Description

"Benzeneethanol, b-amino-a,a-diphenyl-, (bR)-" is a complex organic compound that one likely encounters in scientific research or industrial applications. The (bR)- prefix indicates that it's a specific enantiomer, or mirror-image form, of this molecule, crucial information as different enantiomers can have drastically different functionalities. Benzeneethanol, b-amino-a,a-diphenyl-, (bR)- comprises benzene, a cyclic hydrocarbon, and an ethanol functional group, which contains oxygen and lends the compound certain polar characteristics. The diphenyl indicates two phenyl groups attached to the central carbon atom, and the b-amino refers to the amino group that's on the beta carbon atom from the alcohol group. Due to its specific structure, it likely has specific, dedicated uses in academic or commercial chemistry.

InChI:InChI=1/C20H19NO/c21-19(16-10-4-1-5-11-16)20(22,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15,19,22H,21H2/t19-/m1/s1

Upstream product

• 119-61-9 benzophenone 
• 100-46-9 benzylamine 
• 873977-89-0 hippuric acid-(2-hydroxy-1,2,2-triphenyl-ethylamide) 
• 690629-64-2 N-benzylidene-2-methoxy-1-phenylethanamine 
• 1395342-20-7 2-(2-methoxy-1-phenylethylamino)-1,1,2-triphenylethanol 
• 100-52-7 benzaldehyde 
• 17599-61-0 N-benzylidene-1,1,1-trimethylsilanamine 
• 108-86-1 bromobenzene 
• 19883-41-1 D-phenylglycine methyl ester hydrochloride 
• 1395342-04-7 (R)-2-((S)-2-methoxy-1-phenylethylamino)-1,1,2-triphenylethanol 
• 862776-58-7 (S)-N-benzylidene-2-methylpropane-2-sulfinamide 
• 223930-75-4 ((methoxymethoxy)methylene)dibenzene 
• 157556-88-2 (S)-2,2,3-triphenyloxirane 
• 875-74-1 (R)-phenylglycine 

Downstream Products

• 62183-23-7 4,5,5-triphenyl-oxazolidin-2-one 
• 156481-74-2 (R)-4-phenyl-5,5-diphenyl-oxazolidin-2-one 
• 1733-63-7 1,2,2-triphenylethan-1-one 
• 119-61-9 benzophenone 
• 100-46-9 benzylamine 
• 210582-37-9 C₃₅H₃₉NO₂ 
• 1313712-77-4 C₃₁H₂₅NO₂ 
• 153887-73-1 5-hydro-2,3-benzo-7-diphenil-8-1,4,6-threeoxa-9-aza-5-phospaspiro-<4.4>nonane 
• 93472-50-5 1-methyl-3,4-diphenylisoquinoline 

Relevant articles and documents

Addition of the Lithium Anion of Diphenylmethanol Methyl/Methoxymethyl Ether to Nonracemic Sulfinimines: Two-Step Asymmetric Synthesis of Diphenylprolinol Methyl Ether and Chiral (Diphenylmethoxymethyl)amines

Addition of the lithium anion generated from diphenylmethanol methyl and methoxymethyl ether to nonracemic sulfinimines afforded the corresponding addition products in excellent diastereoselctivity and yields. Deprotection of the MOM as well as sulfinyl groups rendered the enantiopure (diphenylhydroxymethyl)amines in excellent yields. The procedure was applied for a two-step synthesis of diphenylprolinol, a privileged ligand in asymmetric catalysis.

Titanium-mediated cross-coupling reactions of imines with ketones or aldehydes: An efficient route for the synthesis of 1,2-amino alcohols

The cross-coupling reactions of imines with ketones using Ti(O iPr)4/c-C5H9MgCl reagent lead to 1,2-amino alcohols after hydrolysis. The coupling reactions with aldehydes could also afford 1,2-amino alcohols, however, in some cases, aziridines were obtained as major products in a stereoselective manner.

Synthesis of heavily substituted 1,2-amino alcohols in enantiomerically pure form

A simple and convenient methodology for the preparation of optically pure 2-amino-2-aryl-1,1-diphenylethanols is presented. Allylamine was found to produce the ring-opening of triaryloxiranes in a regioselective and a stereospecific fashion. Removal of the allyl protecting group provided the free 1,2-amino alcohols in enantiomerically pure form.