79893-64-4

Upstream product

• 1193-47-1 2,2-dimethyl-cyclohexanone 
• 75-03-6 ethyl iodide 
• 79893-66-6 2-ethyl-6,6-dimethylcyclohex-2-en-1-one 
• 583-60-8 2-Methylcyclohexanone 
• 7379-12-6 n-propyl isopropyl ketone 
• 1431465-12-1 ethyl 1-ethyl-3,3-dimethyl-2-oxocyclohexanecarboxylate 

Downstream Products

• 170710-56-2 (+/-)-4-(2'-ethyl-1'-hydroxy-6',6'-dimethylcyclohexyl)-but-3-yn-2-ol tetrahydropyranyl ether 
• 79893-65-5 (+/-)-4-(2'-ethyl-1'-hydroxy-6',6'-dimethylcyclohexyl)-but-3-yn-2-ol 
• 1431465-14-3 2-ethyl-6,6-dimethyl-2-(2-oxopropyl)cyclohexanone 
• 1431465-13-2 2-allyl-2-ethyl-6,6-dimethylcyclohexanone 
• 79893-66-6 2-ethyl-6,6-dimethylcyclohex-2-en-1-one 
• 132719-15-4 (+/-)-3-(2'-ethyl-1'-hydroxy-6',6'-dimethylcyclohexyl)-1-methyl-2-propynyl acetate 
• 132719-16-5 (+/-)-3-(2'-ethyl-6',6'-dimethyl-1'-cyclohexene-1'-yl)-1-methyl-2-propynyl acetate 
• 132719-14-3 (+/-)-(E)-4-(2'-ethyl-6',6'-dimethyl-1'-cyclohexene-1'-yl)-3-buten-2-one 
• 132719-17-6 (+/-)-(E)-4-(2'-ethyl-6',6'-dimethyl-1'-cyclohexene-1'-yl)-3-buten-2-ol 
• 109530-77-0 (1S,6R)-6-Ethyl-1-ethynyl-2,2-dimethyl-cyclohexanol 
• 109530-78-1 (1S,6S)-6-Ethyl-1-ethynyl-2,2-dimethyl-cyclohexanol 

Relevant academic research and scientific papers

OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

Use of cyclic ketones in perfumery

PCT No. PCT/IB97/01092 Sec. 371 Date May 13, 1998 Sec. 102(e) Date May 13, 1998 PCT Filed Sep. 12, 1997 PCT Pub. No. WO98/13447 PCT Pub. Date Apr. 2, 1998The compounds of formula in which R stands for a methyl or ethyl group, are used as perfume ingredien

Synthesis and Biological Activity of 7'-, 8'-, and 9'-Alkyl Analogues of Abscisic Acid

In order to examine the hypothesis of pseudo-symmetry in the abscisic acid (ABA) molecule, (+/-)-7'-,8'-, and 9'-methyl, and (+/-)-7'-, 8'-, and 9'-ethyl analogues of abscisic acid, whose pseudo-symmetry is decreased, weresynthesized and, after optical resolution, tested for their inhibitory activity in four bioassays.The correlation of the decrease in the activity of (-)-7'- and 9'-alkyl-ABAs with that of (+)-9'- and 7'-alkyl-ABAs, respectively, seemed to agree with the hypothesis.The decrease in activity by alkylating C-8' of (+)-ABA was smaller than that by alkylating C-7' and C-9' of (+)-ABA, indicating that the activity was relatively unaffected by the bulky group at C-8' of (+)-ABA.Alkylation of C-8' and C-9', especially that of C-8', of (-)-ABA markedly reduced the activity.If the high activity of unnatural (-)-ABA is attributable to the pseudo-symmetry of the molecule, C-8' of (-)-ABA would occupy the space facing the re-face of C-2' in natural (+)-ABA.The low activity of (-)-8'-alkyl-ABA suggests the presence of a strict steric requirement of the binding sites to occupy the re-face of C-2' in (+)-ABA.

Retinoids, X. - A Novel Way to 5-Ethyl-18-norretinoids

The synthesis of 5-ethyl-18-norretinal (2) is described; the key step is the cyclization of acrolein (3) with 2-methyl-3-hexanone (4) to 2-ethyl-6,6-dimethyl-2-cyclohexen-1-one (5).