79925-03-4

Usage

Uses

Used in Pharmaceutical Industry:
4-(3-Nitrophenyl)-3-thiosemicarbazide is used as a precursor in the synthesis of various biologically active compounds for pharmaceutical applications. Its versatile reactivity allows for the creation of a wide range of pharmaceutical agents with potential therapeutic effects.
Used in Agricultural Industry:
In the agricultural sector, 4-(3-Nitrophenyl)-3-thiosemicarbazide is used as a starting material for the synthesis of various agrochemicals, including pesticides and herbicides. Its reactivity enables the development of effective compounds for crop protection and management.

InChI:InChI=1/C7H8N4O2S/c8-10-7(14)9-5-2-1-3-6(4-5)11(12)13/h1-4H,8H2,(H2,9,10,14)

Upstream product

• 3529-82-6 3-nitrophenyl isothiocyanate 
• 99-09-2 3-nitro-aniline 
• 75-15-0 carbon disulfide 

Downstream Products

• 1398501-20-6 2-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(3-nitrophenyl)-1-hydrazinecarbothioamide 
• 80650-20-0 (3-Nitro-phenyl)-[1,2,3,4]thiatriazol-5-yl-amine 
• 79924-98-4 (Z)-camphorquinone 4-m-nitrothiosemicarbazone 
• 79924-98-4 (E)-camphorquinone 4-m-nitrothiosemicarbazone 
• 1224696-46-1 C₁₅H₁₄N₄O₃S 
• 7025-16-3 m-NPTSH 

Relevant academic research and scientific papers

Co(II), Ni(II) and Cu(II) complexes with coumarin-8-yl Schiff-bases: Spectroscopic, in vitro antimicrobial, DNA cleavage and fluorescence studies

A new series of Co(II), Ni(II) and Cu(II) complexes of the type ML·2H2O of Schiff-bases derived from m-substituted thiosemicarbazides and 8-acetyl-7-hydroxy-4-methylcoumarin have been synthesized and characterized by spectroscopic studies. Schiff-bases exhibit thiol-thione tautomerism wherein sulphur plays an important role in the coordination. The coordination possibility of the Schiff-bases towards metal ions have been proposed in the light of elemental analyses, spectral (IR, UV-vis, FAB-mass, ESR and fluorescence), magnetic and thermal studies. The low molar conductance values in DMF indicate that, the metal complexes are non-electrolytes. The cyclic voltammetric studies suggested that, the Cu(II) and Ni(II) complexes are of single electron transfer quasi-reversible nature. The Schiff-bases and its metal complexes have been evaluated for their in vitro antibacterial (Escherichia coli, Staphilococcus aureus, Bascillus subtilis and Salmonella typhi) and antifungal activities (Candida albicans, Cladosporium and Aspergillus niger) by MIC method. The Schiff-base I and its metal complexes exhibited DNA cleavage activity on isolated DNA of A. niger.

DNA cleavage, in vitro antimicrobial and electrochemical studies of Co(II), Ni(II), and Cu(II) complexes with m-substituted thiosemicarbazide schiff bases

Co(II), Ni(II), and Cu(II) complexes, ML2 · 2H2O have been synthesized with Schiff bases derived from m-substituted thiosemicarbazides and 2-methoxy benzaldehyde. The complexes are soluble in DMF/DMSO and non-electrolytes. From analy

Synthesis and antibacterial activity of thiosemicarbazones

The synthesis of 1-[(2′-hydroxy-4′-isopropoxy-5′- nitrophenyl)-ethanone]-4-(aryl)-3-thiosemicarbazones are carried out by refluxing 4-aryl-3-thiosemicarbazides and 2-hydroxy-4-isopropoxy-5- nitroacetophenone in stoichiometric amounts dissolved in aqueous

Synthesis and spectral studies of platinum complexes of para-substituted 4-phenylthiosemicarbazides

Platinum(II) complexes of para-substituted 4-phenylthiosemicarbazides, RPhNHCSNHNH2 (R = H, CH3, Br, F and NO2) have been prepared and characterised by infrared and multinuclear NMR spectroscopy. The thiosemicarbazides act as bidentate ligands bonding through the sulphur and hydrazinic nitrogen atoms to form mixtures of cis- and trans-isomers of square planar complexes. 1H and 195Pt NMR spectroscopy suggest that the trans-isomer predominates in solution and that the relative ratio of trans: cis increases with increasing temperature of synthesis. 15N NMR spectroscopy has also been used to assign the cis- and trans-isomers of platinum complexes of 15N enriched 4-(4′-bromophenyl)thiosemicarbazide using 15N chemical shifts and |1J 195Pt-15N| values. The magnitude of the coupling constant |1J 195Pt-15N| of 238 Hz compares favourably with other platinum(II) complexes in which the 15N donor atom is trans to 15N and thus confirms the assignment of the trans-isomer as the predominant one in solution.