79971-33-8

Usage

Uses

Used in Pharmaceutical Industry:
(1,4-dimethoxynaphthalen-2-yl)acetic acid is utilized as a precursor in the synthesis of various drugs and pharmaceutical products, contributing to the development of new medications.
Used in Organic Chemistry:
In the field of organic chemistry, (1,4-dimethoxynaphthalen-2-yl)acetic acid serves as a building block for the synthesis of complex organic molecules, facilitating the creation of intricate chemical structures.
Used in Biological Research:
(1,4-dimethoxynaphthalen-2-yl)acetic acid has been studied for its potential biological activities, such as anti-inflammatory and anti-cancer properties, indicating its possible use in therapeutic applications.

Upstream product

• 79971-24-7 2-(bromomethyl)-1,4-dimethoxynaphthalene 
• 1619226-66-2 1,4-dimethoxy-2-(2-nitroethyl)naphthalene 
• 150556-57-3 1,4-dimethoxy-2-hydroxymethylnaphthalene 
• 75965-83-2 1,4-dimethoxynaphthalene-2-carbaldehyde 
• 10075-62-4 1,4-dimethoxynaphthalene 
• 79971-25-8 2-(cyanomethyl)-1,4-dimethoxynaphthalene 

Downstream Products

• 79971-27-0 1,4-dimethoxy-2-<2,2-dianisyl)vinyl>naphthalene 
• 79971-26-9 dimethoxy-2-<2,2-bisvinyl>naphthalene 
• 79972-39-7 2-(1,4-Dimethoxy-naphthalen-2-yl)-1,1-bis-(4-dimethylamino-phenyl)-ethanol 
• 110271-41-5 psychorubrin 

Relevant academic research and scientific papers

Synthesis of naturally occurring pyranonaphthoquinones: (±) 9-demethoxyeleutherin, (±) 9-demethoxyisoeleutherin, and pentalongin via nef reaction

GRAPHICAL ABSTRACT The article describes alternative method for the synthesis of (±) 9-demethoxyeleutherin and (±) 9-demethoxyisoeleutherin, the analogs of naturally occurring pyranonaphthoquinones antibiotics eleutherin and isoeleutherin. This methodology has provided the target molecules using a shorter route involving five simple chemical transformations with Nef reaction as a key step. All the intermediates and target molecules were completely characterized by spectral techniques and confirmed by comparison with literature data. Further we have extended Nef protocol toward formal synthesis of naturally occuring pyranonaphthoquinone pentalongin. We accomplished synthesis of of 2-(1,4-dimethoxynaphthalen-2-yl) acetic acid devoid of very toxic cyanide intermediates, which has been converted into pentalongin.

Simple synthesis of two naphthoquinone antibiotics psychorubrin and pentalongin

1H-Naphtho[2,3-c]pyran-5,10-dione derivatives were synthesized using chloromethylation of substituted-2-naphthylacetic acid as the key step. The utility of this method was demonstrated in the synthesis of two-pyranonaphthoquinone antibiotics psychorubrin (1) and pentalongin (2).

The synthesis of radermachol

Five different approaches to the preparation of 6,7-benzo-3,4-(1,4-dimethoxy-2,3-naphtho)-1,5-dioxosuberane (3), an intermediate needed for the synthesis of radermachol (1), the red pigment from the roots of Radermachera xylocarpa, are described. The synthesis of radermachol (1) has been accomplished from 1,4-naphthoquinone in 14 steps.