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Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Benzyloxy-3-chlorophenyl)piperazine is used as a chemical intermediate for the preparation of piperazinylphenyl sulfamate derivatives. These derivatives are valuable in the development of pharmaceuticals, particularly those with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 1-(4-Benzyloxy-3-chlorophenyl)piperazine serves as a key building block for the creation of more complex organic molecules. Its unique structure allows for further functionalization and modification, making it a versatile component in the synthesis of various compounds with diverse properties and applications.

Upstream product

• 110-85-0 piperazine 
• 56872-27-6 1-(benzyloxy)-4-bromo-2-chlorobenzene 
• 3964-56-5 4-bromo-2-chlorophenol 
• 100-39-0 benzyl bromide 

Downstream Products

• 85474-76-6 4-Hydroxy-m-chlorophenylpiperazine 
• 871338-83-9 1,1-dimethylethyl 4-[3-chloro-4-(2-morpholin-4-yl-ethoxy)phenyl]piperazine-1-carboxylate 
• 871464-68-5 4-[2-(2-chloro-4-piperazin-1-ylphenoxy)ethyl]morpholine 
• 871338-82-8 1,1-dimethylethyl 4-(3-chloro-4-hydroxyphenyl)-piperazine-1-carboxylate 

Relevant academic research and scientific papers

CYCLIC AMINOPHENYL SULFAMATE DERIVATIVE

This invention provides cyclicamino-phenyl sulfamate derivatives represented by a formula wherein each of R1 and R2 stands for hydrogen or lower alkyl; each of R3 and R4 stands for hydrogen, halogen, cyano or the like; A stands for nitrogen or CH; B stands for CH2, SO2, CO, optionally substituted phenyl or the like; and R5 stands for alkyl, phenyl, amino or the like, or salts thereof which exhibit excellent steroid sulfatase inhibitory activity and are useful for prevention or treatment of diseases associated with steroids such as estrogen, androgen and the like.

KINASE MODULATORS AND METHODS OF USE

The present invention relates to compounds of the Formula I and II wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.