800402-05-5

Basic information

• Product Name: N-(6-chloro-3-iodopyridin-2-yl)pivalaMide
• Synonyms: N-(6-chloro-3-iodopyridin-2-yl)pivalaMide
• CAS NO: 800402-05-5
• Molecular Formula: C₁₀H₁₂ClIN₂O
• Molecular Weight: 338.57255
• Mol File: 800402-05-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(6-chloro-3-iodopyridin-2-yl)pivalaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-chloro-3-iodopyridin-2-yl)pivalaMide(800402-05-5)
• EPA Substance Registry System: N-(6-chloro-3-iodopyridin-2-yl)pivalaMide(800402-05-5)

Safety Data

• Hazardous Substances Data: 800402-05-5(Hazardous Substances Data)

Usage

General Description

N-(6-chloro-3-iodopyridin-2-yl)pivalaMide is a chemical compound with the molecular formula C9H10ClIN2O. It is a pivaloyl derivative of 6-chloro-3-iodo-2-pyridinylamine, containing a pivaloyl group at the amino group. N-(6-chloro-3-iodopyridin-2-yl)pivalaMide is used in the field of organic synthesis, pharmaceuticals, and agrochemicals. It has the potential to act as a building block in the synthesis of various biologically active compounds and pharmaceuticals. The presence of the chloro and iodo substituents on the pyridine ring makes this compound an important intermediate for the synthesis of diverse pharmaceuticals and agrochemicals.

Upstream product

• 45644-21-1 6-chloropyridin-2-amine 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 287384-84-3 6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester 
• 1350353-83-1 C₁₉H₁₇N₅O₂ 
• 1296200-17-3 6-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid 4-methoxybenzylamide 
• 1350353-84-2 SR₈₃₆₃ 
• 1350353-85-3 C₂₀H₁₉N₅O₂ 
• 1296202-59-9 6-chloro-N-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide 
• 1031284-87-3 5-{8-[4-(4-isopropylpiperazin-1-yl)phenylamino]imidazo[1,2-a]pyridin-5-yl}-2,3-dihydro-isoindol-1-one 
• 1031290-25-1 (5-chloroimidazo[1,2-a]pyridin-8-yl)-[4-(4-isopropylpiperazin-1-yl)phenyl]amine 
• 1031289-77-6 5-chloro-8-iodo-imidazo[1,2-a]pyridine 

Relevant articles and documents

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

Rho kinase (ROCK) inhibitors are potential therapeutic agents to treat disorders such as hypertension, multiple sclerosis, cancers, and glaucoma. Here, we disclose the synthesis, optimization, biological evaluation of potent indole and 7-azaindole based ROCK inhibitors that have high potency on ROCK (IC 50 = 1 nM) with 740-fold selectivity over PKA (47). Moreover, 47 showed very good DMPK properties making it a good candidate for further development. Finally, docking studies with a homology model of ROCK-II were performed to rationalize the binding mode of these compounds and showed the compounds bound in both orientations to take advantage to H-bonds with Lys-121 of ROCK-II.

BICYCLIC HETEROARYLS AS KINASE INHIBITORS

The invention is directed to heteroaryl compounds useful as inhibitors of various kinase enzymes. In various embodiments, the invention provides a heteroaryl compound having inhibitory bioactivity with respect to a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Flt kinase, an Aurora kinase, or a Src kinase, or any combination thereof. Compounds of the invention include bicyclic heteroaryl compounds of formula (I), which can contain a bridging nitrogen atom at a ring junction. The invention further provides methods of synthesis of compounds of the invention, pharmaceutical compositions, pharmaceutical combinations, and methods of treatment of malconditions using compounds of the invention.