1-(2-bromo-4,5-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2,3-dione, also known as KW-2449, is a synthetic isoquinoline derivative with potential anti-tumor activity. It targets various cancer cell lines, including lung cancer, breast cancer, and leukemia, by inhibiting the activity of the tyrosine kinase enzyme, which is crucial for cell proliferation and growth.
80041-82-3
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Basic information
- Product Name: 1-(2-bromo-4,5-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2,3-dione
- Synonyms:
- CAS NO:80041-82-3
- Molecular Formula: C22H20BrNO6
- Molecular Weight: 474.3013
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 611.5°C at 760 mmHg
- Flash Point: 323.6°C
- Appearance: N/A
- Density: 1.56g/cm3
- Vapor Pressure: 6.8E-15mmHg at 25°C
- Refractive Index: 1.657
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 1-(2-bromo-4,5-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2,3-dione(CAS DataBase Reference)
- NIST Chemistry Reference: 1-(2-bromo-4,5-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2,3-dione(80041-82-3)
- EPA Substance Registry System: 1-(2-bromo-4,5-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2,3-dione(80041-82-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 80041-82-3(Hazardous Substances Data)
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80041-82-3 Usage
Uses
Used in Pharmaceutical Industry:KW-2449 is used as a potential drug candidate for the treatment of various types of cancer. It works by inducing apoptosis in cancer cells and inhibiting tumor growth in animal models, making it a promising option for cancer therapy.
Used in Cancer Research:
In the field of cancer research, KW-2449 is used as a tool to study the mechanisms of cancer cell proliferation and the role of tyrosine kinase enzymes in tumor growth. 1-(2-bromo-4,5-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2,3-dione helps researchers understand the pathways involved in cancer development and identify potential targets for therapeutic intervention.
Used in Drug Development:
KW-2449 is utilized in the development of new drugs targeting cancer cells. Its ability to inhibit the tyrosine kinase enzyme and induce apoptosis makes it a valuable compound in the creation of novel anti-cancer medications.
Used in Preclinical Trials:
As a potential anti-tumor agent, KW-2449 is used in preclinical trials to evaluate its safety, efficacy, and potential side effects before moving on to human clinical trials. These trials are essential in determining the compound's suitability as a therapeutic option for cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 80041-82-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,0,4 and 1 respectively; the second part has 2 digits, 8 and 2 respectively.Calculate Digit Verification of CAS Registry Number 80041-82:
(7*8)+(6*0)+(5*0)+(4*4)+(3*1)+(2*8)+(1*2)=93
93 % 10 = 3
So 80041-82-3 is a valid CAS Registry Number.
80041-82-3Upstream product
80041-82-3Downstream Products
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1-(2-bromo-4,5-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2,3-dione
