80065-56-1

Usage

InChI:InChI=1/C23H26F3N3O2/c1-4-6-16(13-27)29-18-12-19(30-3)22(20-14(2)9-10-28-21(18)20)31-17-8-5-7-15(11-17)23(24,25)26/h5,7-12,16,29H,4,6,13,27H2,1-3H3

Upstream product

• 82333-37-7 6-methoxy-4-methyl-8-nitro-5-<3-(trifluoromethyl)phenoxy>quinoline 
• 82333-41-3 8-amino-6-methoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline 
• 160088-53-9 N-(5-chloro-4-methoxy-2-nitrophenyl)-acetamide 
• 98-17-9 3-Trifluoromethylphenol 
• 110-15-6 succinic acid 
• 80065-55-0 8-<(4-amino-1-methylbutyl)amino>-6-methoxy-4-methyl-5-<3-(trifluoromethyl)phenoxy>quinoline 
• 1061346-40-4 C₁₄H₁₁F₃N₂O₄*ClH 
• 98081-50-6 4-acetamino-5-nitro-2-(3-trifluoromethylphenyloxy)anisole 

Downstream Products

• 82333-38-8 5-(2,4-Dichlorophenoxy)-6-methoxy-4-methyl-8-nitroquinoline 

Relevant academic research and scientific papers

Inhibition of human monoamine oxidase A and B by 5-phenoxy 8-aminoquinoline analogs

8-Aminoquinolines (8-AQs) are important class of anti-infective therapeutics. 5-Phenoxy 8-aminoquinoline analogs have shown improved metabolic stability compared to primaquine. In view or predictive role of monoamine oxidases (MAO) in metabolism of 8-amin

4-Methyl-5-(unsubstituted and substituted phenoxy)-6-methoxy-8-(aminoalkylamino)quinolines

Compounds of the class including 4-methyl-5-(unsubstituted and substitutedhenoxy)-6-methoxy-8-(aminoalkylamino)quinolines as the free bases and pharmaceutically acceptable acid amine salts are described. The compounds are highly effective antimalarial agents which possess, surprisingly, both tissue schizonticidal (radical curative) and blood schizonticidal (suppressive) activity. In addition, these drugs have significantly better therapeutics indices than primaquine which is the current tissue schizonticidal drug of choice. Primaquine possesses no useful blood schizonticidal activity at tolerated dose levels.