80087-27-0

Basic information

• Product Name: 2-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]-1-phenylethanone
• Synonyms: 2-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]-1-phenylethanone
• CAS NO: 80087-27-0
• Molecular Weight: 234.282
• Mol File: 80087-27-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]-1-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]-1-phenylethanone(80087-27-0)
• EPA Substance Registry System: 2-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]-1-phenylethanone(80087-27-0)

Safety Data

• Hazardous Substances Data: 80087-27-0(Hazardous Substances Data)

Upstream product

• 74-88-4 methyl iodide 
• 98-86-2 acetophenone 
• 13183-79-4 1-methyl-5-mercaptotetrazole 

Relevant articles and documents

Preparation method of alpha-heterocycle sulfide ketone compound

The invention provides a method for efficiently synthesizing different heterocycle sulfide ketone derivatives. According to the method, KI is adopted as a catalyst, potassium persulfate is adopted as an oxidizing agent, a carbonyl compound and benzoheterocycle mercaptan are taken as reaction substrates at room temperature, and DMSO is added into a reaction system as a solvent. The method provided by the invention has the advantages that the catalyst is cheap and available; reaction conditions are mild, and reaction can be carried out at room temperature, thereby being safe and reliable; and the highest yield of the obtained target product reaches 94%. The method provided by the invention overcomes the defects that a substrate of the traditional heterocycle thio etherification reaction is expensive, multi-step reaction is required to be carried out and reaction conditions are harsh, and the method provided by the invention has a good industrial application prospect.

Iodine Promoted Regioselective α-Sulfenylation of Carbonyl Compounds using Dimethyl Sulfoxide as an Oxidant

A metal-free regioselective sulfenylation of the α-CH3 group of ketones has been achieved in the presence of the α-CH2 or α-CH group using the cross dehydrogenative (CDC) strategy. Aldehydes also exhibit good selectivity forming the corresponding α-sulfenylated products. This efficient sulfenylation of ketones or aldehydes with thiones or heterocyclic thiols utilizes dimethyl sulfoxide (DMSO) as an oxidant in the presence of iodine. This eco-friendly method uses readily available and inexpensive I2 and DMSO. The application of this methodology has been demonstrated by synthesizing precursors for Julia- Kocienski olefination intermediates.

TETRAZOLE DERIVATIVES, AND ANTI-ULCER COMPOSITION CONTAINING THE SAME

Tetrazole derivatives of the formula: STR1 wherein R 1 is a lower alkykl, phenyl or a group of the formula:--S(O) l--A--(X) m--R 3, and R 2 is hydrogen, a lower alkyl, phenyl or a cycloalkyl when R 1 is the group--S(O) l--A--(X) m--R 3, or R 2 is a group of the formula:--B--CO--R 4 when R 1 is a lower alkyl or phenyl and a pharmaceutically acceptable salt thereof, which have prophylactic or therapeutic activities against peptic and/or duodenal ulcers and are useful as an anti-ulcer drug; processes for the preparation of the tetrazole derivatives; and pharmaceutical composition containing said tetrazole derivatives.