80087-27-0Relevant academic research and scientific papers
Preparation method of alpha-heterocycle sulfide ketone compound
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Paragraph 0036; 0037, (2017/08/30)
The invention provides a method for efficiently synthesizing different heterocycle sulfide ketone derivatives. According to the method, KI is adopted as a catalyst, potassium persulfate is adopted as an oxidizing agent, a carbonyl compound and benzoheterocycle mercaptan are taken as reaction substrates at room temperature, and DMSO is added into a reaction system as a solvent. The method provided by the invention has the advantages that the catalyst is cheap and available; reaction conditions are mild, and reaction can be carried out at room temperature, thereby being safe and reliable; and the highest yield of the obtained target product reaches 94%. The method provided by the invention overcomes the defects that a substrate of the traditional heterocycle thio etherification reaction is expensive, multi-step reaction is required to be carried out and reaction conditions are harsh, and the method provided by the invention has a good industrial application prospect.
KI/K 2 S 2 O 8 -Mediated α-C-H Sulfenylation of Carbonyl Compounds with (Hetero)Aryl Thiols
Yang, Zan,Li, Jiao,Hua, Jie,Yang, Tao,Yi, Jianmin,Zhou, Congshan
supporting information, p. 2325 - 2329 (2017/10/06)
A new and facile KI/K 2 S 2 O 8 -mediated α-C-H sulfenylation of carbonyl compounds with (hetero)aryl thiols was developed for the formation of C-S bond at room temperature. This method provided a simple process for the sy
Iodine Promoted Regioselective α-Sulfenylation of Carbonyl Compounds using Dimethyl Sulfoxide as an Oxidant
Siddaraju, Yogesh,Prabhu, Kandikere Ramaiah
supporting information, p. 6090 - 6093 (2016/12/09)
A metal-free regioselective sulfenylation of the α-CH3 group of ketones has been achieved in the presence of the α-CH2 or α-CH group using the cross dehydrogenative (CDC) strategy. Aldehydes also exhibit good selectivity forming the corresponding α-sulfenylated products. This efficient sulfenylation of ketones or aldehydes with thiones or heterocyclic thiols utilizes dimethyl sulfoxide (DMSO) as an oxidant in the presence of iodine. This eco-friendly method uses readily available and inexpensive I2 and DMSO. The application of this methodology has been demonstrated by synthesizing precursors for Julia- Kocienski olefination intermediates.
Synthesis of 2-substituted tetrazole-5-thiols and 5,5′- disulfandiylbis(2-Alkyl-2H-Tetrazoles)
Vorona,Artamonova,Kitchenko,Zevatskii,Myznikov
, p. 496 - 502 (2014/08/05)
A method has been proposed for the synthesis of 2-alkyltetrazole-5-thiols. It was shown that these compounds are readily oxidized to the corresponding disulfides and their further functionalization has been studied.
TETRAZOLE DERIVATIVES, AND ANTI-ULCER COMPOSITION CONTAINING THE SAME
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, (2008/06/13)
Tetrazole derivatives of the formula: STR1 wherein R 1 is a lower alkykl, phenyl or a group of the formula:--S(O) l--A--(X) m--R 3, and R 2 is hydrogen, a lower alkyl, phenyl or a cycloalkyl when R 1 is the group--S(O) l--A--(X) m--R 3, or R 2 is a group of the formula:--B--CO--R 4 when R 1 is a lower alkyl or phenyl and a pharmaceutically acceptable salt thereof, which have prophylactic or therapeutic activities against peptic and/or duodenal ulcers and are useful as an anti-ulcer drug; processes for the preparation of the tetrazole derivatives; and pharmaceutical composition containing said tetrazole derivatives.
