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80102-23-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 80102-23-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,1,0 and 2 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 80102-23:
74 % 10 = 4
So 80102-23-4 is a valid CAS Registry Number.

80102-23-4 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (H61107)  N-Boc-2-chloro-D-phenylalanine, 95%   

  • 80102-23-4

  • 1g

  • 818.0CNY

  • Detail
  • Alfa Aesar

  • (H61107)  N-Boc-2-chloro-D-phenylalanine, 95%   

  • 80102-23-4

  • 5g

  • 3674.0CNY

  • Detail
  • Aldrich

  • (15018)  Boc-D-Phe(2-Cl)-OH  ≥98.0% (TLC)

  • 80102-23-4

  • 15018-5G

  • 2,678.13CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name Boc-D-Phe(2-Cl)-OH

1.2 Other means of identification

Product number -
Other names (2R)-3-(2-chlorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:80102-23-4 SDS

80102-23-4Relevant articles and documents

2H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design

Giroud, Maude,Kuhn, Bernd,Saint-Auret, Sarah,Kuratli, Christoph,Martin, Rainer E.,Schuler, Franz,Diederich, Fran?ois,Kaiser, Marcel,Brun, Reto,Schirmeister, Tanja,Haap, Wolfgang

, p. 3370 - 3388 (2018/05/01)

Macrocyclic inhibitors of rhodesain (RD), a parasitic cysteine protease and drug target for the treatment of human African trypanosomiasis, have shown low metabolic stability at the macrocyclic ether bridge. A series of acyclic dipeptidyl nitriles was developed using structure-based design (PDB ID: 6EX8). The selectivity against the closely related cysteine protease human cathepsin L (hCatL) was substantially improved, up to 507-fold. In the S2 pocket, 3,4-dichlorophenylalanine residues provided high trypanocidal activities. In the S3 pocket, aromatic residues provided enhanced selectivity against hCatL. RD inhibition (Ki values) and in vitro cell-growth of Trypanosoma brucei rhodesiense (IC50 values) were measured in the nanomolar range. Triazole-based ligands, obtained by a safe, gram-scale flow production of ethyl 1H-1,2,3-triazole-4-carboxylate, showed excellent metabolic stability in human liver microsomes and in vivo half-lives of up to 1.53 h in mice. When orally administered to infected mice, parasitaemia was reduced but without complete removal of the parasites.

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