801163-54-2Relevant articles and documents
PROCESS FOR PREPARING ARYL KETONE
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, (2017/06/12)
A process for preparing aryl ketones is disclosed. The process includes photo-oxidizing a compound of formula (V), (VI), (VII) or (VIII): in the presence of an oxidative system comprising at least one bromide compound to form aryl ketones. X1, X2, R1, R2, R3, L1, L2, L3, L4, t, n, m and p have the meanings as described in the specification and claims.
Et2Zn-mediated rearrangement of bromohydrins
Li, Lezhen,Cai, Peijie,Guo, Qingxiang,Xue, Song
, p. 3516 - 3522 (2008/09/20)
(Chemical Equation Presented) A simple and highly efficient method for the rearrangement of bromohydrins mediated by Et2Zn to synthesize carbonyl compounds was described. Various β-bromo alcohols were treated with 0.6 equiv of Et2Zn to form a zinc complex in CH 2Cl2 at room temperature for 2 h, followed by 1,2-migration to give the corresponding carbonyl compounds. This remarkable and clean rearrangement is general for acyclic and cyclic bromohydrins, and a variety of ring-expansive and -contractive carbonyl compounds were obtained in good to excellent yields according to the feature of the starting bromohydrins. The functional group tolerance of organozinc reagents in this reaction will be useful in organic synthesis. The scope and limitations of this rearrangement process were also investigated.