801223-71-2Relevant academic research and scientific papers
Discovery of new G-quadruplex binding chemotypes
Ohnmacht, Stephan A.,Varavipour, Ehsan,Nanjunda, Rupesh,Pazitna, Ingrida,Di Vita, Gloria,Gunaratnam, Mekala,Kumar, Arvind,Ismail, Mohamed A.,Boykin, David W.,Wilson, W. David,Neidle, Stephen
supporting information, p. 960 - 963 (2014/01/06)
We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent
Structural selectivity of aromatic diamidines
Chaires, Jonathan B.,Ren, Jinsong,Hamelberg, Donald,Kumar, Arvind,Pandya, Vandna,Boykin, David W.,Wilson, W. David
, p. 5729 - 5742 (2007/10/03)
Competition dialysis was used to study the interactions of 13 substituted aromatic diamidine compounds with 13 nucleic acid structures and sequences. The results show a striking selectivity of these compounds for the triplex structure poly dA:(poly dT)su
