801239-76-9Relevant academic research and scientific papers
Chemical adaptor immunotherapy: Design, synthesis, and evaluation of novel integrin-targeting devices
Li, Lian-Sheng,Rader, Christoph,Matsushita, Masayuki,Das, Sanjib,Barbas III, Carlos F.,Lerner, Richard A.,Sinha, Subhash C.
, p. 5630 - 5640 (2007/10/03)
A series of β-diketone derivatives of RGD peptidomimetics that selectively bind to αvβ3 and αvβ5 integrins were synthesized and covalently docked to the reactive lysine residues of monoclonal aldolase antibody 38C2. The resulting targeting devices strongl
Vitronectin receptor antagonist pharmaceuticals
-
, (2008/06/13)
The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The present invention further provides novel compounds useful for imaging atherosclerosis, restenosis, cardiac ischemia and myocardial reperfusion injury. The present invention still further provides novel compounds useful for the treatment of rheumatoid arthritis. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.
