801281-99-2

Usage

InChI:InChI=1/C12H16FNO3/c1-12(2,3)17-11(15)14-8-6-5-7-9(16-4)10(8)13/h5-7H,1-4H3,(H,14,15)

Upstream product

• 801282-00-8 2-fluoro-3-methoxyaniline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 137654-20-7 2-fluoro-3-methoxybenzoic acid 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 1057720-39-4 tert-butyl N-[6-bromo-2-fluoro-3-methoxyphenyl]carbamate 
• 1272719-23-9 C₉H₅FN₂OS 
• 1272719-07-9 3-fluoro-4-[3-(4-fluoro-phenyl)-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl]-2-methoxy-benzonitrile 
• 1272719-08-0 4-[4,4-dimethyl-3-(6-methyl-pyridin-3-yl)-5-oxo-2-thioxo-imidazolidin-1-yl]-3-fluoro-2-methoxy-benzonitrile 
• 1272719-09-1 3-fluoro-4-[3-(4-methanesulfonyl-phenyl)-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl]-2-methoxy-benzonitrile 
• 1272719-10-4 4-[3-(4-cyano-2-fluoro-3-methoxy-phenyl)-5,5-dimethyl-4-oxo-2-thioxo-imidazolidin-1-yl]-2-fluoro-N-methyl-benzamide 
• 1272719-11-5 4-(4,4-dimethyl-5-oxo-2-thioxo-3-p-tolyl-imidazolidin-1-yl)-3-fluoro-2-methoxy-benzonitrile 
• 1272719-12-6 3-fluoro-4-[3-(3-fluoro-4-methyl-phenyl)-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl]-2-methoxy-benzonitrile 
• 1272719-18-2 4-(4,4-dimethyl-5-oxo-2-thioxo-3-p-cyanophenyl-imidazolidin-1-yl)-3-fluoro-2-methoxy-benzonitrile 
• 1272719-19-3 C₇H₇BrFNO 
• 1272719-20-6 C₉H₉BrFNO₂ 
• 1272719-21-7 C₁₀H₉FN₂O₂ 
• 1272719-22-8 C₈H₇FN₂O 
• 1357176-75-0 2-fluoro-3-methoxyaniline hydrochloride 

Relevant academic research and scientific papers

ANDROGEN RECEPTOR ANTAGONISTS AND USES THEREOF

Disclosed are substituted thioimidazolidinone compounds and pharmaceutical compositions comprising such compounds. The compounds and compositions can be used for treatment of androgen receptor-associated diseases or disorders, such as prostate cancer, benign prostatic hypertrophy, male hair loss and hypertrichosis.

INDAZOLE- AND PYRROLOPYRIDINE-DERIVATIVE AND PHARMACEUTICAL USE THEREOF

The present invention relates to a novel indazole- or pyrrolopyridine-derivative, represented by the formula (1) below, that has an agonistic action or a partial agonistic action against serotonin-4 receptor, and a pharmaceutical composition comprising the same. Formula (1) [wherein each substituent is as defined in claim 1]

ANDROGEN RECEPTOR ANTAGONISTS AND USES THEREOF

The present invention relates to novel substituted thioimidazolidinone compounds and pharmaceutical compositions comprising such compounds for treatment of androgen receptor-associated diseases or disorders, such as prostate cancer, benign prostatic hypertrophy, male hair loss, muscle loss, acne and hirsutism.

Nucleus- and side-chain fluorinated 3-substituted indoles by a suitable combination of organometallic and radical chemistry

Regioselectively fluoro-, trifluoromethyl- and trifluoromethoxy-substituted 3-methyleneindolines have been prepared using a four-step procedure involving metalation/bromination of fluorinated Boc-protected anilines, N-propargylation of the resulting o-bro

HEPATITIS C INHIBITOR COMPOUNDS

Compounds of formula (I): wherein B, X, R3, L0, L1, L2, R2, R1 and RC are defined herein. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection.