80129-52-8 Usage
Uses
Used in Pharmaceutical Synthesis:
4-Hydroxy-1H-indole-2-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique chemical structure allows for the development of new drugs with potential therapeutic benefits.
Used in Drug Discovery and Development:
4-Hydroxy-1H-indole-2-carboxylic acid is used as a starting material in drug discovery and development. Its pharmacological properties make it a promising candidate for the creation of new therapeutic agents that can target specific biological pathways and diseases.
Used in Metabolic Studies:
As a metabolite of tryptophan, 4-Hydroxy-1H-indole-2-carboxylic acid is used in metabolic studies to understand the role of tryptophan in various physiological processes and its potential impact on health and disease.
Used in Plant Biology Research:
4-Hydroxy-1H-indole-2-carboxylic acid is found in some plant tissues, making it a valuable compound for plant biology research. It can be used to study the biosynthesis of indole compounds in plants and their potential applications in agriculture and medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 80129-52-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,1,2 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 80129-52:
(7*8)+(6*0)+(5*1)+(4*2)+(3*9)+(2*5)+(1*2)=108
108 % 10 = 8
So 80129-52-8 is a valid CAS Registry Number.
80129-52-8Relevant academic research and scientific papers
Novel Indole-2-carboxylates as Ligands for the Strychnine-Insensitive N-Methyl-D-aspartate-Linked Glycine Receptor
Gray, Nancy M.,Dappen, Michael S.,Cheng, Brian K.,Cordi, Alexis A.,Biesterfeldt, John P.,et al.
, p. 1283 - 1292 (2007/10/02)
A series of indole-2-carboxylates were prepared and evaluated for their ability to inhibit the binding at the strychnine-insensitive glycine receptor that is associated with the NMDA-PCP-glycine receptor complex.All of the compounds were selective for the glycine site relative to other sites on the receptor macrocomplex and several of the compounds in this series were found to have submicromolar affinity for this receptor.The lead compound, 2-carboxy-6-chloro-3-indoleacetic acid (Ki = 1.6 μM vsglycine), was also found to noncompetitively inhibit the binding of MK-801, a ligand for the phencyclidine site on the receptor macrocomplex.These latter data suggest that the compound functions as an antagonist at the strychnine-insensitive glycine receptor.The structural activity relationships within this series of indole-2-carboxylates is discussed and several key pharmacophores are identified for this series of glycine ligands.In general, the most potent compounds were the C-3 acetamides, with N-propyl-2-carboxy-6-chloro-3-indoleacetamide having the highest receptor affinity.
