801316-48-3Relevant academic research and scientific papers
Practical synthesis of a potent hepatitis C virus RNA replication inhibitor
Bio, Matthew M.,Xu, Feng,Waters, Marjorie,Williams, J. Michael,Savary, Kimberly A.,Cowden, Cameron J.,Yang, Chunhua,Buck, Elizabeth,Song, Zhiguo J.,Tschaen, David M.,Volante,Reamer, Robert A.,Grabowski, Edward J. J.
, p. 6257 - 6266 (2007/10/03)
A practical, efficient synthesis of 1, a hepatitis C virus RNA replication inhibitor, is described. Starting with the inexpensive diacetone glucose, the 12-step synthesis features a novel stereoselective rearrangement to prepare the key crystalline furanose diol intermediate. This is followed by a highly selective glycosidation to couple the C-2 branched furanose epoxide with deazapurine.
Preparation of C-3,5-acyl furanoses via highly selective intramolecular acyl migration
Xu, Feng,Simmons, Bryon,Savary, Kimberly,Yang, Chunhua,Reamer, Robert A.
, p. 7783 - 7786 (2007/10/03)
A practical synthesis of C-3,5-acyl furanose via a base-catalyzed, highly selective intramolecular acyl migration in alcohol solvents is reported.
