801317-51-1Relevant articles and documents
Synthesis and antiaggregatory activity of RGD-peptidomimetics based on 4-oxo-4-(piperazine-1-yl)butyric acid as Arg-mimetic
Andronati, Sergei A.,Krysko, Andrei A.,Kabanov, Vladimir M.,Kabanova, Tatyana A.,Karaseva, Tamara L.,Chugunov, Boris M.,Meshkova, Svetlana B.,Topilova, Zoya M.
, p. 375 - 381 (2007/10/03)
A scheme of synthesis of previously obtained RGDF-peptidomimetic-4-oxo- 4-(piperazine-1-yl)butyrylglycyl-D,L-β-phenyl-β-alanine (I), was simplified. The novel RGDF-peptidomimetic - 4-o-xo-4-(piperazine-1-yl) butyryl-glycyl-L-aspartyl-L-phenylalanine (II was synthesized with the use of 4-oxo-4-(piperazine-1-yl)butyric acid as arginyl mimetic. The obtained pseudopeptides were able to inhibit both platelet aggregation in human blood and binding of fibrinogen to its receptor.