288851-44-5

Basic information

• Product Name: 4-(3-CARBOXY-PROPIONYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: BUTTPARK 82\11-12;1-BOC-4-(3-CARBOXY-PROPIONYL)-PIPERAZINE;4-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]-4-OXOBUTANOIC ACID;4-(3-CARBOXY-PROPIONYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(3-Carboxy-propionyl)-piperazine-1-carboxylic
• CAS NO: 288851-44-5
• Molecular Formula: C₁₃H₂₂N₂O₅
• Molecular Weight: 286.32
• Product Categories: piperazines
• Mol File: 288851-44-5.mol

Chemical Properties

• Melting Point: 127-129°C
• Boiling Point: 473.6°Cat760mmHg
• Flash Point: 240.2°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 2.82E-10mmHg at 25°C
• Refractive Index: 1.512
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(3-CARBOXY-PROPIONYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-CARBOXY-PROPIONYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(288851-44-5)
• EPA Substance Registry System: 4-(3-CARBOXY-PROPIONYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(288851-44-5)

Safety Data

• Hazardous Substances Data: 288851-44-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
4-(3-Carboxy-propionyl)-piperazine-1-carboxylic acid tert-butyl ester is used as a building block in the synthesis of pharmaceuticals. Its unique structure and functional groups make it a valuable component in the development of new drugs and therapeutic agents.
Used in Agrochemical Production:
4-(3-CARBOXY-PROPIONYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is also utilized in the production of agrochemicals, where it serves as a key intermediate in the synthesis of various pesticides and other agricultural chemicals.
Used in Polymer and Material Science:
4-(3-Carboxy-propionyl)-piperazine-1-carboxylic acid tert-butyl ester is employed in the field of polymer and material science for the production of different types of polymers and materials. Its versatility and reactivity contribute to the creation of innovative materials with specific properties for various applications.
Used in Organic Chemistry Research:
As a versatile ester compound, 4-(3-Carboxy-propionyl)-piperazine-1-carboxylic acid tert-butyl ester is used in organic chemistry research for studying reaction mechanisms, exploring new synthetic routes, and developing novel chemical transformations.

InChI:InChI=1/C13H22N2O5/c1-13(2,3)20-12(19)15-8-6-14(7-9-15)10(16)4-5-11(17)18/h4-9H2,1-3H3,(H,17,18)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 72547-43-4 4-oxo-4-piperazin-1-yl-butyric acid 
• 108-30-5 succinic acid anhydride 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 329911-78-6 methyl (4-[4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutyryl]glycyl-D,L-β-phenyl-β-alaninate 
• 801317-53-3 4-oxo-4-(4-Boc-piperazin-1-yl)butyryl-glycyl-L-aspartyl-L-phenylalanine 
• 801317-51-1 4-oxo-4-(4-Boc-piperazin-1-yl)butyrylglycine pentafluorophenyl ether 
• 329911-79-7 (4-[4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutyryl]glycyl-D,L-β-phenyl-β-alanine 
• 858555-40-5 m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]benzoyl-β-(3,4-methylenedioxyphenyl)-β-alanine 
• 858555-36-9 succinimidyl m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]benzoate 
• 858555-32-5 m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]-benzoic acid 
• 329911-76-4 pentafluorophenyl 4-(4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutanoate 

Relevant articles and documents

Calcium-promoted hydrolysis of N-acylureas allows mild release of peptides anchored with Dpr(Phoc) linker to hydrophilic resins

Calcium chloride is an efficient additive for promoting the release of short peptide models anchored with Dpr(Phoc) linker to hydrophilic solid-phase synthesis supports. It was shown to induce a moderate to marked (especially for C-terminal proline peptides) increase in the rate of alkaline hydrolytic cleavage, without epimerization at the C-terminal residue, while substantially reducing the hydroxide ion concentration. Base-promoted side-reactions are therefore expected to be slowed down.

METHODS, MIXTURES, KITS AND COMPOSITIONS PERTAINING TO ANALYTE DETERMINATION

This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination by mass spectrometry.

Synthesis and antiaggregation activity of a new RGDF peptidomimetic

A new RGDF peptidomimetic, [4-oxo-4-(pyperazin-1-yl)butyryl]glycyl-D,L-β-phenyl-β-alanine was synthesized. The arginyl mimetic used was the 4-oxo-4-(piperazin-1-yl)butanoic acid residue, and the Asp-Phe chain is replaced by a β-phenyl-β-alanine residue. The synthesized pseudopeptide showed ability to inhibite ADF-induced thrombocyte aggregation in a thrombocyte-rich rat blood plasma (IC50 8.7 × 10-9 M).

Synthesis and properties of peptidomimetics - Inhibitors of platelet aggregation

The literature data on effective approaches to the development of the novel peptidomimetics, antagonists of fibrinogen GP IIb/IIIa receptors as potential antithrombotic agents are generalized and systematized in the review. The data obtained by the authors on the synthesis and properties of novel peptidomimetics are reported.