288851-44-5 Usage
General Description
4-(3-Carboxy-propionyl)-piperazine-1-carboxylic acid tert-butyl ester is a chemical compound that falls under the category of esters, which are organic compounds derived from an acid in which at least one -OH (hydroxyl) group is replaced by an -O-alkyl group. This specific compound contains a piperazine ring and a carboxylic acid functional group, along with a tert-butyl ester. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of various polymers and materials. The tert-butyl ester group in this compound serves to protect the carboxylic acid group, preventing unwanted reactions and allowing for selective manipulation in chemical reactions. Overall, 4-(3-Carboxy-propionyl)-piperazine-1-carboxylic acid tert-butyl ester is a versatile compound with wide-ranging applications in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 288851-44-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,8,8,5 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 288851-44:
(8*2)+(7*8)+(6*8)+(5*8)+(4*5)+(3*1)+(2*4)+(1*4)=195
195 % 10 = 5
So 288851-44-5 is a valid CAS Registry Number.
InChI:InChI=1/C13H22N2O5/c1-13(2,3)20-12(19)15-8-6-14(7-9-15)10(16)4-5-11(17)18/h4-9H2,1-3H3,(H,17,18)
288851-44-5Relevant articles and documents
Calcium-promoted hydrolysis of N-acylureas allows mild release of peptides anchored with Dpr(Phoc) linker to hydrophilic resins
Pascal, Robert,Sola, Regine
, p. 4549 - 4552 (1997)
Calcium chloride is an efficient additive for promoting the release of short peptide models anchored with Dpr(Phoc) linker to hydrophilic solid-phase synthesis supports. It was shown to induce a moderate to marked (especially for C-terminal proline peptides) increase in the rate of alkaline hydrolytic cleavage, without epimerization at the C-terminal residue, while substantially reducing the hydroxide ion concentration. Base-promoted side-reactions are therefore expected to be slowed down.
Synthesis and antiaggregation activity of a new RGDF peptidomimetic
Krys'ko,Kabanov,Polishchuk,Chugunov,Pavlovskii,Andronati,Mazepa,Kabanova,Karaseva
, p. 948 - 952 (2007/10/03)
A new RGDF peptidomimetic, [4-oxo-4-(pyperazin-1-yl)butyryl]glycyl-D,L-β-phenyl-β-alanine was synthesized. The arginyl mimetic used was the 4-oxo-4-(piperazin-1-yl)butanoic acid residue, and the Asp-Phe chain is replaced by a β-phenyl-β-alanine residue. The synthesized pseudopeptide showed ability to inhibite ADF-induced thrombocyte aggregation in a thrombocyte-rich rat blood plasma (IC50 8.7 × 10-9 M).
