329911-79-7

Upstream product

• 84796-63-4 β-phenylalanine 
• 801317-50-0 4-oxo-4-(4-Boc-piperazin-1-yl)butyrylglycine 
• 3646-50-2 3-Amino-3-phenylpropionic acid 
• 801317-52-2 4-oxo-4-(4-Boc-piperazin-1-yl)butyrylglycine succinimide ether 
• 801317-51-1 4-oxo-4-(4-Boc-piperazin-1-yl)butyrylglycine pentafluorophenyl ether 
• 288851-44-5 4-(4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutanoic acid 
• 329911-77-5 methyl tert-butoxycarbonyl-glycyl-D,L-β-phenyl-β-alaninate 
• 22838-46-6 methyl 3-amino-3-phenylpropionate hydrochloride 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 801317-49-7 4-oxo-4-(4-Boc-piperazin-1-yl)butyric acid succinimide ether 
• 329911-76-4 pentafluorophenyl 4-(4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutanoate 
• 329911-78-6 methyl (4-[4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutyryl]glycyl-D,L-β-phenyl-β-alaninate 

Relevant academic research and scientific papers

Synthesis and antiaggregatory activity of RGD-peptidomimetics based on 4-oxo-4-(piperazine-1-yl)butyric acid as Arg-mimetic

A scheme of synthesis of previously obtained RGDF-peptidomimetic-4-oxo- 4-(piperazine-1-yl)butyrylglycyl-D,L-β-phenyl-β-alanine (I), was simplified. The novel RGDF-peptidomimetic - 4-o-xo-4-(piperazine-1-yl) butyryl-glycyl-L-aspartyl-L-phenylalanine (II was synthesized with the use of 4-oxo-4-(piperazine-1-yl)butyric acid as arginyl mimetic. The obtained pseudopeptides were able to inhibit both platelet aggregation in human blood and binding of fibrinogen to its receptor.

Synthesis and antiaggregation activity of a new RGDF peptidomimetic

A new RGDF peptidomimetic, [4-oxo-4-(pyperazin-1-yl)butyryl]glycyl-D,L-β-phenyl-β-alanine was synthesized. The arginyl mimetic used was the 4-oxo-4-(piperazin-1-yl)butanoic acid residue, and the Asp-Phe chain is replaced by a β-phenyl-β-alanine residue. The synthesized pseudopeptide showed ability to inhibite ADF-induced thrombocyte aggregation in a thrombocyte-rich rat blood plasma (IC50 8.7 × 10-9 M).

Synthesis and properties of peptidomimetics - Inhibitors of platelet aggregation

The literature data on effective approaches to the development of the novel peptidomimetics, antagonists of fibrinogen GP IIb/IIIa receptors as potential antithrombotic agents are generalized and systematized in the review. The data obtained by the authors on the synthesis and properties of novel peptidomimetics are reported.