80140-30-3Relevant academic research and scientific papers
Nobiletin metabolites: Synthesis and inhibitory activity against matrix metalloproteinase-9 production
Oshitari, Tetsuta,Okuyama, Yuji,Miyata, Yoshiki,Kosano, Hiroshi,Takahashi, Hideyo,Natsugari, Hideaki
, p. 4540 - 4544 (2011/09/12)
A divergent synthesis of nobiletin metabolites was developed through highly oxygenated acetophenone derivative. We used commercially available methyl 3,4,5-trimethoxybenzoate as a starting material for concise preparation of the key intermediate, 2′-hydro
Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines
Li, Shiming,Pan, Min-Hsiung,Lai, Ching-Shu,Lo, Chih-Yu,Dushenkov, Slavik,Ho, Chi-Tang
, p. 3381 - 3389 (2008/02/07)
Fifteen polymethoxyflavones (PMFs) and hydroxylated PMFs were isolated from sweet orange (Citrus sinensis) peel extract and synthesized to investigate their biological activity. All obtained compounds were tested in HL-60 cancer cell proliferation and apoptosis induction assays. While some PMFs and hydroxylated PMFs had moderate anti-carcinogenic activities, 5-hydroxy-6,7,8,3′,4′-pentamethoxyflavone and 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone showed strong inhibitory activities against the proliferation and induced apoptosis of HL-60 cell lines.
Inhibitor of aldose reductase
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, (2008/06/13)
An inhibitor of aldose reductase which contains, as the effective ingredient, a flavone derivative having the following formula: STR1 wherein R1 is hydrogen atom or hydroxyl group, R2 is hydroxyl group or methoxyl group or a pharmace
Synthesis of 5,3',4'-Trihydroxy-6,7,8-trimethoxyflavone
Bhardwaj, D. K.,Gupta, A. K.,Jain, R. K.
, p. 800 - 801 (2007/10/02)
The structure of a new trihydroxytrimethoxyflavone, isolated from Sideritis leucantha, as 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone (I) has now been confirmed by its synthesis. 2-(3',4'-Dibenzyloxy)benzoyloxy-3,4,5,6-tetramethoxyacetophenone (VI) on Bake
