80167-62-0Relevant academic research and scientific papers
Addition of secondary amines to maleamic esters and maleimides
Bergman, Jan,Brimert, Thomas
, p. 48 - 56 (2007/10/03)
Contrary to some literature claims, secondary amines such as piperidine or their acetates do not promote the cyclization of maleanilic esters with activated orthoalkyl groups to form 2-quinolones, but instead they add to the maleic double bond, to produce 3-aminosuccinimides or 3-aminosuccinamic esters, depending on the conditions used. This and similar reactions were studied and also an alternative synthesis of 7-nitro-3-(2-oxo-2-piperidin-1-ylethyl)-3,4-dihydroquinolin-2(1H)-one was achieved utilizing the Schmidt reaction as the key step. Copyright Acta Chemica Scandinavica 1999.
Reactions of Cyclic Anhydrides: Part VI - Transesterification of Maleanilic and Fumaranilic Acids with Phosphorus Pentoxide-Alkanol
Wagh, S. B.,Balasubramaniyan, P.,Balasubramaniyan, V.
, p. 577 - 578 (2007/10/02)
Mixed phosphorus esters obtained from alkanols and phosphorus pentoxide furnish the corresponding esters in 80-90percent yield when refluxed with maleanilic and fumaranilic acids.
