80217-67-0Relevant academic research and scientific papers
Synthesis, characterization and anticancer activity of novel ferrocene containing quinolinones: 1-Allyl-2-ferrocenyl-2,3-dihydroquinolin-4(1H)-ones and 1-allyl-2-ferrocenylquinolin-4(1H)-ones
Pejovi?, Anka,Drabowicz, Józef,Cieslak, Marcin,Kazmierczak-Baranska, Julia,Królewska-Golińska, Karolina
, p. 78 - 85 (2018)
A two new series of ferrocene containing quinolinones – 1-allyl-2-ferrocenyl-2,3-dihydroquinolin-4(1H)-ones and 1-allyl-2-ferrocenylquinolin-4(1H)-ones – were prepared and characterized by standard spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against Human Cervix Carcinoma (HeLa), Chronic Myelogenous Leukemia (K562) and normal endothelial (HUVEC) cell lines using the MTT method. Quinolone derivative 5c exhibited the highest cytotoxic activity in the cell growth inhibition of HeLa cell line while 5f was the most toxic against K562 cells.
A 1, 2 - disubstituted - 4 - quinolone and its synthesis method (by machine translation)
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Paragraph 0037, (2017/08/29)
The invention relates to a 1, 2 - disubstituted - 4 - quinolone and its synthetic method, preempt substituted acyl chloride dissolved in a solvent, then adding N - substituted ortho amino acetophenone, stir, thereby obtaining a reaction system; wherein the substituted acyl chloride and N - substituted ortho amino acetophenone in a molar ratio of 1: (1 - 1.1), and then to the alkali is added to the reaction system, in 25 - 60 °C reaction, after the reaction is complete by extraction, extraction, drying and evaporate the solvent, get 1, 2 - disubstituted - 4 - quinolone. This invention adopts the substituted acyl chloride and N - substituted ortho amino acetophenone reaction, raw materials are easy, simple preparation, the atom utilization rate is high, the yield is high; mild reaction conditions, does not require high temperature heating and reflux, in the 25 - 60 °C reaction, saves the preparation cost of the reaction process; avoids the use of a flammable and explosive phenylacetylene and raw materials such as n - BuLi; not require noble metal catalyst, the cost is reduced, at the same time also reduces the pollution of the environment. (by machine translation)
Direct synthesis of 2-aryl-4-quinolones via transition-metal-free intramolecular oxidative C(sp3)-H/C(sp3)-H coupling
Hu, Wei,Lin, Jian-Ping,Song, Li-Rui,Long, Ya-Qiu
supporting information, p. 1268 - 1271 (2015/05/20)
A novel, metal-free oxidative intramolecular Mannich reaction was developed between secondary amines and unmodified ketones, affording a simple and direct access to a broad range of 2-arylquinolin-4(1H)-ones through C(sp3)-H activation/C(sp3)-C(sp3) bond formation from readily available N-arylmethyl-2-aminophenylketones, using TEMPO as the oxidant and KOtBu as the base.
Copper-catalyzed intramolecular oxidative C(sp3)-H amidation of 2-aminoacetophenones: Efficient synthesis of indoline-2,3-diones
Huang, Jinbo,Mao, Tingting,Zhu, Qiang
supporting information, p. 2878 - 2882 (2014/05/20)
An efficient synthesis of diverse indoline-2,3-diones from 2-aminoacetophenones through copper-catalyzed intramolecular C(sp3)-H amidation is developed. The reaction proceeds in DMSO by using O2 as the sole oxidant to provide the desired products in moderate to good yields.
A practical, metal-free synthesis of 1H-Lndazoles
Counceller, Carla M.,Eichman, Chad C.,Wray, Brertda C.,Stambuli, James P.
supporting information; experimental part, p. 1021 - 1023 (2009/04/07)
The synthesis of 1H-indazoles is achieved from o-aminobenzoximes by the selective activation of the oxime in the presence of the amino group. The reaction occurs with a variety of substituted o-aminobenzoximes using a slight excess of methanesulfonyl chloride and triethylamine at 0-23 °C and is amenable to scale-up. The synthesis of 1 H-indazoles under these conditions is extremely mild compared with previous synthetic approaches and affords the desired compounds in good to excellent yields.
A convenient approach to cyclic enol phosphates via ring-closing metathesis
Whitehead, Alan,Moore, Joel D.,Hanson, Paul R.
, p. 4275 - 4277 (2007/10/03)
A strategy employing the second generation Grubbs catalyst in order to facilitate the generation of a variety of cyclic enol phosphates, including 2H-chromen-4-yl, 1,2-dihydroquinolin-4-yl, 2H-thiochromen-4-yl, 2H-thiochromen-4-yl 1,1-dioxide, and benzofu
