80221-38-1

Basic information

• Product Name: 4-piperidineacetic acid, 1-benzoyl-, methyl ester
• Synonyms: 4-piperidineacetic acid, 1-benzoyl-, methyl ester;methyl (1-benzoylpiperidin-4-yl)acetate;2-[1-(benzoyl)-4-piperidyl]acetic acid methyl ester;2-[1-(oxo-phenylmethyl)-4-piperidinyl]acetic acid methyl ester;methyl 2-(1-phenylcarbonylpiperidin-4-yl)ethanoate;methyl 2-[1-(benzoyl)-4-piperidyl]acetate;methyl 2-[1-(benzoyl)piperidin-4-yl]acetate
• CAS NO: 80221-38-1
• Molecular Formula: C15H19NO3
• Molecular Weight: 261.31626
• Mol File: 80221-38-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-piperidineacetic acid, 1-benzoyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-piperidineacetic acid, 1-benzoyl-, methyl ester(80221-38-1)
• EPA Substance Registry System: 4-piperidineacetic acid, 1-benzoyl-, methyl ester(80221-38-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 80221-38-1(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 81270-37-3 methyl piperidine-4-acetate hydrochloride 

Relevant articles and documents

Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors

We report here the strategy used in our research group to find a new class of histone deacetylase (HDAC) inhibitors. A series of N-substituted 4-alkylpiperazine and 4-alkylpiperidine hydroxamic acids, corresponding to the basic structure of HDAC inhibitors (zinc binding moiety-linker-capping group) has been designed, prepared, and tested for HDAC inhibition. Linker length and aromatic capping group connection were systematically varied to find the optimal geometric parameters. A new series of submicromolar inhibitors was thus identified, which showed antiproliferative activity on HCT-116 colon carcinoma cells.