80232-86-6

Upstream product

• 106270-39-7 2-phenyl-2,4,5,6,7,7a-hexahydro-benzothiazole 
• 51595-54-1 1-Chlor-7-oxa-bicyclo<4.1.0>heptan 
• 2227-79-4 benzenecarbothioamide 
• 122687-60-9 2-phenyl-3-thia-1-azaspiro[4,4]non-1-ene-4-thione 
• 124292-86-0 2-isopropoxy-1-aza-4-oxaspiro[4.5]dec-1-en-3-one 
• 124292-93-9 4-Isopropoxy-2-phenyl-2-trifluoromethyl-2H-oxazol-5-one 
• 42904-05-2 α-mercaptocyclohexanone 
• 100-52-7 benzaldehyde 
• 1170696-56-6 C₁₃H₁₄BrNS 
• 108-94-1 cyclohexanone 
• 137858-58-3 2-benzamidocyclohexanone 

Downstream Products

• 883-93-2 2-Phenylbenzothiazole 

Relevant academic research and scientific papers

Four-component thiazole formation from simple chemicals under metal-free conditions

Multi-component reactions for the synthesis of polysubstituted thiazoles from simple chemicals are described. Under metal-free reaction conditions, cheap and easily available ketones, aldehydes, ammonium salt, and elemental sulfur are self-assembled to provide entries to three thiazoles in moderate to good yield with a range of functionalities tolerated.

Substituted azole penta-heterocyclic derivatives and solvothermal one-pot synthesis method and application thereof

The invention belongs to the technical field of organic synthesis and particularly discloses a series of substituted azole penta-heterocyclic derivatives and a solvothermal one-pot synthesis method thereof. By the adoption of the solvothermal one-pot synthesis method for preparing the target product, reaction time is short, a solvent is not prone to volatilization in an airtight system, recycling can be realized, production cost is effectively reduced, the advantages of energy conservation and environment friendliness are achieved, operation is easy, yield is high, and the prepared substituted azole penta-heterocyclic derivatives have good anti-microbial biological activity and excellent photophysical properties such as electron conductivity, the fluorescence property and the ultraviolet property, thereby having very high development and application value.

Intramolecular nucleophilic substitution at an sp2 carbon: synthesis of substituted thiazoles and imidazole-2-thiones

The nucleophilic substitution reactions of vinylic bromides with intramolecular thioamide or thiourea moieties proceed to give a series of substituted thiazoles and imidazole-2-thiones.

Direct α-oxytosylation of carbonyl compounds: One-pot synthesis of heterocycles

N-Methyl-O-tosylhydroxylamine is an effective reagent for the direct α-oxytosylation of carbonyl compounds. The reactions proceed smoothly at room temperature in the presence of both moisture and air and functional group tolerance in the substrate is good. With nonsymmetrical substrates regioselectivity for primary over secondary centers is observed and complete regiospecificity for primary over tertiary centers is obtained. Addition of a bis-heteronucleophile directly to the crude reaction mixture in a one-pot process leads to the corresponding heterocyclic product.

1,3-dipolar cycloadditions with 1-alkoxy-substituted nitrile ylides

Thermolysis of 4-alkoxy-1,3-oxazol-5(2H)-ones (2) (X = O) leads to reactive nitrile ylides (1) bearing an alkoxy substituent at the nitrile C-atom. These intermediates can be trapped by C,C-, C,O-, C,N-, and C,S-dipolarophiles, yielding 5-membered heterocycles via 1,3-dipolar cycloaddition. In the case of 1,3-thiazole-5(4H)-thiones (11) as dipolarophiles, two regioisomeric cycloadducts were obtained. The results of the cycloadditions are discussed with respect to the influence of the alkoxy substituent on the structure of the nitrile ylide.

SYNTHETIC APPLICATIONS OF 2-CHLOROOXIRANES: PREPARATION OF THIAZOLES, DIHYDROTHIAZOLES AND SELENAZOLES

The reaction of 2-chlorooxiranes 1 with thioamides and thioureas provides access to thiazoles, 4-hydroxy-4,5-dihydrothiazoles and 2-imino-2,3-dihydrothiazoles under mild conditions and excellent yields.With 1 and selenourea, near quantitative yields of se