80239-81-2

Upstream product

• 108-98-5 thiophenol 
• 619-23-8 3-Nitrobenzyl chloride 
• 930-69-8 sodium thiophenolate 
• 619-25-0 3-Nitrobenzyl alcohol 

Downstream Products

• 34111-96-1 (3-nitro-benzyl)-phenyl sulfone 
• 99-08-1 1-methyl-3-nitrobenzene 
• 139-66-2 diphenyl sulfide 
• 99-61-6 3-nitro-benzaldehyde 
• 19829-61-9 3,3'-dinitrobibenzyl 
• 882-33-7 diphenyldisulfane 
• 80239-80-1 3-<(phenylthio)methyl>aniline hydrochloride 
• 1403988-66-8 4-chloro-N-{3-[(phenylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine 
• 135294-61-0 3-benzenesulfonylmethyl-aniline 
• 129527-28-2 1-(Benzenesulfonyl-bis-methylsulfanyl-methyl)-3-nitro-benzene 
• 129527-21-5 1-(Benzenesulfonyl-methylsulfanyl-methyl)-3-nitro-benzene 
• 87739-40-0 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-<3-<(phenylthio)methyl>phenyl>-s-triazine hydrochloride 

Relevant academic research and scientific papers

A comparison of the inhibition of growth of methotrexate-resistant and -sensitive leukemia cells in culture by triazines. Evidence for a new mechanism of cell resistance to methotrexate

Forty-five 4,6-diamino-1,2-dihydro-1,2-dimethyl-1-(3-X-phenyl)-s-triazine inhibitors of dihydrofolate reductase (DHFR) and methotrexate (MTX) were tested on L5178Y/R murine tumor cell culture. The concentration of inhibitor causing a 50% decrease in growt

One-pot palladium-catalyzed borrowing hydrogen synthesis of thioethers

Palladium on magnesium oxide is able to allow a one-pot reaction to synthesize thioethers from thiols and aldehydes formed in situ from the respective alcohol by means of a borrowing hydrogen method. The reaction is initiated by dehydrogenation of the alcohol to give a palladium hydride intermediate and an aldehyde. The latter reacts with a thiol involving most probably the intermediacy of a thionium ion RCHi￡S+R, which can be reduced in situ by the metal hydride to afford thioethers. Lending support: Palladium nanoparticles on MgO catalyze the synthesis of thioethers from thiols and aldehydes formed in situ from alcohols by means of the borrowing hydrogen method (see scheme). Dehydrogenation of the alcohol gives a palladium hydride intermediate and an aldehyde. The latter reacts with a thiol through a thionium ion, which is reduced by the metal hydride to afford thioethers.

SUBSTITUTED 4-ARYL-N-PHENYL-1,3,5-TRIAZIN-2-AMINES

The present invention relates to substituted 4-Aryl-N-phenyl-1,3,5-triazin-2-amines of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hy