80254-68-8

Usage

Uses

Used in Pharmaceutical Industry:
3-Fluoro-3'-methoxybiphenyl is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and properties make it a valuable building block for the development of new drugs with improved efficacy and selectivity.
Used in Organic Synthesis:
In the field of organic synthesis, 3-Fluoro-3'-methoxybiphenyl serves as a key component in the preparation of a wide range of organic compounds. Its reactivity and stability contribute to the synthesis of complex molecules with potential applications in various industries.
Used in Chemical Research:
3-Fluoro-3'-methoxybiphenyl is utilized in chemical research to study the effects of fluorination and methoxylation on the properties and reactivity of biphenyl derivatives. This research helps in understanding the fundamental aspects of chemical reactions and contributes to the development of new synthetic methods and strategies.
Used in Material Science:
3-Fluoro-3'-methoxybiphenyl has potential applications in material science, where its unique properties can be exploited to develop new materials with improved performance characteristics. These materials can be used in various applications, such as sensors, coatings, and advanced materials for electronic devices.

Upstream product

• 462-06-6 fluorobenzene 
• 766-85-8 3-methoxy-1-iodobenzene 
• 372-18-9 1,3-Difluorobenzene 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 10365-98-7 3-methoxyphenylboronic acid 
• 1073-06-9 3-fluorobromobenzene 

Downstream Products

• 80254-64-4 1,1'-biphenyl-3'-fluoro-3-ol 

Relevant academic research and scientific papers

Cobalt-Catalyzed Biaryl Couplings via C-F Bond Activation in the Absence of Phosphine or NHC Ligands

A highly general and selective Co-catalyzed biaryl coupling through C-F cleavage under phosphine or NHC-free conditions was described. A broad range of aryl fluorides including unactivated fluorides as well as those with sensitive functionalities could couple with various Ti(OEt)4-mediated aryl Grignard reagents with high selectivity under the catalysis of CoCl2/DMPU. Importantly, selective C-F bond activation couplings between two types of fluorines (difluorinated aromatics and on two different coupling partners) and in the presence of C-Cl or C-Br bonds could also be achieved.

Palladium-catalyzed Suzuki-Miyaura coupling of aryl sulfamates with arylboronic acids

Readily available NHC-Pd(ii)-Mp complexes 2 showed efficient catalytic activity toward the Suzuki-Miyaura coupling of aryl sulfamates with arylboronic acids or potassium phenyltrifluoroborate, giving the expected coupling products in good to high yields.

Air-stable and catalytically active phosphinous acid transition-metal complexes

Secondary phosphane oxides R2P(O)H are most frequently used as preligands for phosphinous acid R2POH (R = alkyl, aryl) transition-metal complexes, which are very efficient catalysts for cross-coupling reactions. To investigate the influence of electron-deficient substituents on the catalytic activity, the coordination properties of bis(trifluoromethyl)-, bis(pentafluoroethyl)-, and bis[2,4-bis(trifluoromethyl) phenyl]phosphinous acid toward catalytically relevant metals, such as palladium and platinum, are studied. The novel phosphinous acid palladium complexes reveal a high catalytic activity in Heck and Suzuki cross-coupling reactions. Because of the strong dependence of these processes on the reaction conditions, a systematic solvent and base screening with 1-bromo-3-fluorobenzene and phenyl boronic acid as model reactants is performed. The most efficient solvent/base system consists of 2-propanol and potassium phosphate, providing a full conversion and a TON of around 10 000 after 20 h at room temperature with a catalyst loading of 0.01 mol % palladium. A catalyst loading of only 0.004 mol % palladium still leads to a nearly full conversion after 20 h at room temperature. During the catalytic reaction, the formation of the corresponding phosphinic acid R2P(O)OH is observed. Further investigations lead to the conclusion that palladium nanoparticles represent the catalytically active species. We also succeeded in the generation of palladium nanoparticles, which exhibit an extremely high catalytic activity in Suzuki cross-coupling reaction with TONs over 60 000 and TOFs larger than 40 000.

Cyclohexylcarbamic acid 3′- or 4′-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: Synthesis, quantitative structure-activity relationships, and molecular modeling studies

Fatty acid amide hydrolase (FAAH) is a promising target for modulating endocannabinoid and fatty acid ethanolamide signaling, which may have important therapeutic potential. We recently described a new class of O-arylcarbamate inhibitors of FAAH, includin

F-NMR-spectroscopy for the identification of photo products generated from aromatic iodo compounds - IV

The investigation demonstrates the analytical power of F-NMR spectroscopy for the identification of isomeric substituted fluorobiphenyls.The biphenyls are formed by u.v. irradiation of iodobenzenes in aromatic solvents.A special procedure for the identification is outlined and tendencies of the results-chemical shifts and relative rates for the production of isomers-are discussed in consideration of electronic and steric substituent effects.