80254-64-4

Usage

Chemical structure

Fluorinated derivative of biphenyl with a fluorine atom attached to the biphenyl ring and a hydroxyl group at the para position on one of the benzene rings.

Industrial relevance

Common industrial chemical and byproduct of coal tar.

Organic synthesis

Used as a starting material for the synthesis of various functionalized biphenyl derivatives.

Pharmaceutical manufacturing

Used in the synthesis of new drugs and pharmaceutical compounds.

Chemical reactions

Acts as a reagent to introduce a fluorine atom into organic molecules.

Potential applications

Development of new drugs and pharmaceutical compounds in medicinal chemistry.

Upstream product

• 462-06-6 fluorobenzene 
• 626-02-8 3-Iodophenol 
• 1121-86-4 1-Fluoro-3-iodobenzene 
• 108-95-2 phenol 
• 504411-52-3 3-(3-fluorophenyl)cyclohexan-1-one 
• 591-20-8 3-Bromophenol 
• 768-35-4 3-fluorophenylboronic acid 
• 10365-98-7 3-methoxyphenylboronic acid 
• 1073-06-9 3-fluorobromobenzene 
• 80254-68-8 3'-fluoro-3-methoxybiphenyl 

Downstream Products

• 733713-71-8 [8-(3-Fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepin-5-yl]-heptyl-amine 
• 141123-94-6 8-(3-Fluoro-phenyl)-3,4-dihydro-2H-benzo[b]oxepin-5-one 

Relevant academic research and scientific papers

One-pot catalysis of dehydrogenation of cyclohexanones to phenols and oxidative Heck coupling: Expedient synthesis of coumarins

One-pot reactions leading to highly functionalized coumarins have been developed via a Pd(ii)-catalyzed dehydrogenation-oxidative Heck-cyclization process.

DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS

The present invention provides novel 6-substituted [1,2,4]triazolo[4,3-b]pyridazines that are agonists of Rev-Erb. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the activation of Rev-Erb has therapeutic effects, for instance in inflammatory and circadian rhythm-related disorders or cardiometabolic diseases.

8-Azabicyclo[3.2.1]octane derivatives

The present invention relates to a 8-azabicyclo[3.2.1]octane derivative of Formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt thereof or solvate thereof. The present invention also relates to a pharmaceutical composition comprising an 8-azabicyclo[3.2.1]octane derivative in admixture with one or more pharmaceutically acceptable auxiliaries and to the use of the 8-azabicyclo[3.2.1]octane derivative in therapy.

Cyclohexylcarbamic acid 3′- or 4′-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: Synthesis, quantitative structure-activity relationships, and molecular modeling studies

Fatty acid amide hydrolase (FAAH) is a promising target for modulating endocannabinoid and fatty acid ethanolamide signaling, which may have important therapeutic potential. We recently described a new class of O-arylcarbamate inhibitors of FAAH, includin

F-NMR-spectroscopy for the identification of photo products generated from aromatic iodo compounds - IV

The investigation demonstrates the analytical power of F-NMR spectroscopy for the identification of isomeric substituted fluorobiphenyls.The biphenyls are formed by u.v. irradiation of iodobenzenes in aromatic solvents.A special procedure for the identification is outlined and tendencies of the results-chemical shifts and relative rates for the production of isomers-are discussed in consideration of electronic and steric substituent effects.