80277-41-4

Basic information

• Product Name: (2-FLUORO-PHENYL)-OXO-ACETONITRILE
• Synonyms: 2-FLUOROBENZOYL CYANIDE;(2-FLUORO-PHENYL)-OXO-ACETONITRILE;Benzeneacetonitrile, 2-fluoro-alpha-oxo- (9CI);(2-Floro-phenyl)-oxo-acetonitrile;2-Fluoro-Alpha-Oxo-Benzeneacetonitrile
• CAS NO: 80277-41-4
• Molecular Formula: C₈H₄FNO
• Molecular Weight: 149.12
• Product Categories: HALIDE
• Mol File: 80277-41-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 219 °C at 760 mmHg
• Flash Point: 86.3 °C
• Appearance: /
• Density: 1.257 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: at 25 deg C (mg/L): 1.876e+004
• CAS DataBase Reference: (2-FLUORO-PHENYL)-OXO-ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-FLUORO-PHENYL)-OXO-ACETONITRILE(80277-41-4)
• EPA Substance Registry System: (2-FLUORO-PHENYL)-OXO-ACETONITRILE(80277-41-4)

Safety Data

• Hazardous Substances Data: 80277-41-4(Hazardous Substances Data)

Usage

Description

(2-FLUORO-PHENYL)-OXO-ACETONITRILE, an acetonitrile derivative, is a chemical compound distinguished by its fluorine-substituted phenyl ring and a ketone group, where a carbon atom is double-bonded to an oxygen atom. This unique structure and reactivity render it a valuable intermediate in the synthesis of complex organic compounds, particularly in the pharmaceutical and agrochemical industries.

Uses

Used in Pharmaceutical Industry:
(2-FLUORO-PHENYL)-OXO-ACETONITRILE is used as a versatile building block for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of complex organic compounds with potential therapeutic applications, contributing to the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, (2-FLUORO-PHENYL)-OXO-ACETONITRILE serves as a key intermediate in the production of agrochemicals. Its reactivity and structural properties enable the synthesis of compounds with pesticidal or herbicidal properties, enhancing crop protection and yield.
Used in Research and Development:
(2-FLUORO-PHENYL)-OXO-ACETONITRILE is utilized in research and development contexts for the preparation of novel chemical entities. Its ability to undergo various chemical reactions makes it a suitable starting material for creating diverse functionalized molecules with potential biological or industrial applications, driving innovation in chemical research.
Used as a Starting Material for Organic Synthesis:
(2-FLUORO-PHENYL)-OXO-ACETONITRILE is used as a starting material in organic synthesis, where it can be further reacted to form a wide range of functionalized molecules. This versatility makes it an essential component in the synthesis of various organic compounds for different applications across industries.

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 393-52-2 2-Fluorobenzoyl chloride 
• 1711-06-4 3-Methylbenzoyl chloride 

Downstream Products

• 132115-73-2 methyl 2-fluoro-α-oxo-benzeneacetate 
• 131513-64-9 4-(2-fluorophenyl)-2,4-butanedione 

Relevant articles and documents

Rh-Catalyzed Asymmetric Hydrogenation of 1,2-Dicyanoalkenes

A highly efficient enantioselective hydrogenation of 1,2-dicyanoalkenes catalyzed by the complex of rhodium and f-spiroPhos has been developed. A series of 1,2-dicyanoalkenes were successfully hydrogenated to the corresponding chiral 1,2-dicyanoalkanes under mild conditions with excellent enantioselectivities (up to 98% ee). This methodology provides efficient access to the asymmetric synthesis of chiral diamines.

Oxime amides and hydrazone amides having fungicidal activity

The invention relates to compounds having usefulness in the control of Take-All disease in plants, particularly cereals, a method for the control of Take-All disease, and fungicidal compositions for carrying out the method. Compounds of the invention are oximes or hydrazones of arylgloxamides or heteroarylglyoxamides or cycloalkenylglyoxamides.

Tin Chloride-Catalyzed Preparation of Aroyl Cyanides from Aroyl Chlorides and Cyanotrimethylsilane

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