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Usage

Uses

Used in Pharmaceutical Industry:
(2-FLUORO-PHENYL)-OXO-ACETONITRILE is used as a versatile building block for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of complex organic compounds with potential therapeutic applications, contributing to the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, (2-FLUORO-PHENYL)-OXO-ACETONITRILE serves as a key intermediate in the production of agrochemicals. Its reactivity and structural properties enable the synthesis of compounds with pesticidal or herbicidal properties, enhancing crop protection and yield.
Used in Research and Development:
(2-FLUORO-PHENYL)-OXO-ACETONITRILE is utilized in research and development contexts for the preparation of novel chemical entities. Its ability to undergo various chemical reactions makes it a suitable starting material for creating diverse functionalized molecules with potential biological or industrial applications, driving innovation in chemical research.
Used as a Starting Material for Organic Synthesis:
(2-FLUORO-PHENYL)-OXO-ACETONITRILE is used as a starting material in organic synthesis, where it can be further reacted to form a wide range of functionalized molecules. This versatility makes it an essential component in the synthesis of various organic compounds for different applications across industries.

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 393-52-2 2-Fluorobenzoyl chloride 
• 1711-06-4 3-Methylbenzoyl chloride 

Downstream Products

• 132115-73-2 methyl 2-fluoro-α-oxo-benzeneacetate 
• 131513-64-9 4-(2-fluorophenyl)-2,4-butanedione 

Relevant academic research and scientific papers

Rh-Catalyzed Asymmetric Hydrogenation of 1,2-Dicyanoalkenes

A highly efficient enantioselective hydrogenation of 1,2-dicyanoalkenes catalyzed by the complex of rhodium and f-spiroPhos has been developed. A series of 1,2-dicyanoalkenes were successfully hydrogenated to the corresponding chiral 1,2-dicyanoalkanes under mild conditions with excellent enantioselectivities (up to 98% ee). This methodology provides efficient access to the asymmetric synthesis of chiral diamines.

Oxime amides and hydrazone amides having fungicidal activity

The invention relates to compounds having usefulness in the control of Take-All disease in plants, particularly cereals, a method for the control of Take-All disease, and fungicidal compositions for carrying out the method. Compounds of the invention are oximes or hydrazones of arylgloxamides or heteroarylglyoxamides or cycloalkenylglyoxamides.

Oxime amides and hydrazone amides having fungicidal activity

The invention relates to compounds having usefulness in the control of Take-All disease in plants, particularly cereals, a method for the control of Take-All disease, and fungicidal compositions for carrying out the method. Compounds of the invention are oximes or hydrazones of arylgloxamides or heteroarylglyoxamides or cycloalkenylglyoxamides.

Chemical process

According to the present invention there is provided process for preparing a compound of formula (I): STR1 or a salt, acylate or sulphonate derivative thereof; wherein R1 is an optionally substituted aryl group, R2, R3, R4 and R5 are selected from hydrogen, C1-4 alkyl, C1-4 alkanoyl or --CO2 Ra wherein Ra is C1-4 alkyl or R2 and R3 or R4 and R5 together with the carbon atom to which they are attached form a C3-6 cycloalkyl ring, provided that at least R2 and R3 or R4 and R5 are not both hydrogen and that not more than two of R2, R3, R4 and R5 are C1-4 alkanoyl or --CO2 Ra ; which process comprises reacting a compound of formula (II): STR2 wherein R2, R3, R4 and R5 are as defined in relation to formula (I) with a compound of formula (III): wherein R1 is as defined in relation to formula (I) in the presence of a base and a Lewis acid.