80287-36-1

Upstream product

• 689277-88-1 (-)-(2S,5S)-2-[(tert-butyldimethylsilanyloxy)-(3,4-dimethoxyphenyl)methyl]but-3-en-1-ol 
• 689277-90-5 (-)-(2S,5S)-4-[(tert-butyldimethylsilanyloxy)-(3,4-dimethoxyphenyl)methyl]-3-[4-(tert-butyldimethylsilanyloxy)-3-methoxybenzyl]dihydrofuran-2-one 
• 689277-89-2 (-)-(2S,5S)-thiocarbonic acid O-{2-[(tert-butyldimethylsilanyloxy)-(3,4-dimethoxyphenyl)methyl]but-3-enyl} ester O-[4-(tert-butyldimethylsilanyloxy)-3-methoxyphenyl] ester 
• 689277-87-0 (+)-(2S,5S)-4-benzyl-3-{2-[(tert-butyldimethylsilanyloxy)-(3,4-dimethoxyphenyl)methyl]but-3-enoyl}oxazolidin-2-one 
• 864369-29-9 (S)-4-Benzyl-3-{(S)-2-[(S)-(3,4-dimethoxy-phenyl)-hydroxy-methyl]-but-3-enoyl}-oxazolidin-2-one 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 74861-40-8 (7'S,8R,8'R)-4,7'-dihydroxy-3,3',4'-trimethoxylignano-9,9'-lactone 
• 69232-85-5 4-(3,4-dimethoxybenzyl)-3-(4'-acetoxy-3'-methoxybenzyl)dihydrofuran-2(3H)-one 
• 546-67-8 lead(IV) tetraacetate 
• 64-19-7 acetic acid 

Downstream Products

• 74861-43-1 β-conidendrin monomethyl ether 
• 71772-18-4 α-conidendrin dimethyl ether 
• 21966-92-7 isolariciresinol dimethyl ether 
• 25253-30-9 β-conidendrin dimethyl ether 

Relevant academic research and scientific papers

Radical carboxyarylation approach to lignans. Total synthesis of (-)-arctigenin, (-)-matairesinol, and related natural products

Total syntheses of seven biologically important lignan natural products, including (-)-arctigenin, (-)-matairesinol, and (-)α-conidendrin, by way of a highly stereoselective domino radical sequence is presented. The reported stereochemistry of the natural product 7-hydroxyarctigenin is shown to be erroneous; a diastereoisomeric structure is assigned to the natural product.