80306-65-6

Upstream product

• 100-52-7 benzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 107-91-5 cyanoacetic acid amide 
• 109-77-3 malononitrile 
• 959-23-9 4'-methoxychalcone 
• 2025-40-3 ethyl benzylidenecyanoacetate 
• 16616-43-6 1-(4-methoxy-phenyl)-3-phenyl-propynone 

Downstream Products

• 171071-13-9 Acetic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[3-cyano-6-(4-methoxy-phenyl)-2-oxo-4-phenyl-2H-pyridin-1-yl]-tetrahydro-pyran-3-yl ester 
• 171071-05-9 Acetic acid (2R,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[3-cyano-6-(4-methoxy-phenyl)-2-oxo-4-phenyl-2H-pyridin-1-yl]-tetrahydro-pyran-3-yl ester 

Relevant academic research and scientific papers

Synthesis of new substituted pyridine derivatives as potent anti-liver cancer agents through apoptosis induction: In vitro, in vivo, and in silico integrated approaches

Liver cancer is the most common type of cancer in many countries. New studies and statistics show rising liver cancer worldwide, so it is essential to seek new agents for this type of cancer. PIM1 has an attractive target in the discovery of cancer medica

Synthesis and anticancer properties of novel hydrazone derivatives incorporating pyridine and isatin moieties

Nine novel hydrazone derivatives (4a–i) incorporating pyridine and isatin moieties were synthesized through one-pot, four-component heterocyclic condensation reactions. The structures of all new compounds (2a–e, 3a, 3c–e, and 4a–e) were identified by sup

One-Pot Synthesis of 3-Cyano-2-pyridones

A versatile synthesis of 3-cyano-2-pyridones via a one-pot, four-component condensation of ethyl cyanoacetate, ketones, aldehydes, and ammonium acetate under very mild conditions has been developed. This method provides rapid access to this type of valuab

One-pot synthesis of 4,6-diaryl-2-oxo-1,2-dihydropyridine-3-carbonitriles via three-component cyclocondensation under solvent-free conditions

An efficient and facile synthesis of 4,6-diaryl-2-oxo-1,2-dihydropyridine- 3-carbonitriles via three-component cyclocondensation from aromatic aldehydes, aromatic ketones, and 2-cyanoacetamide under solvent-free conditions is described. The mild reaction

An efficient and facile procedure for the synthesis of 4,6-diaryl-2(1H)- pyridones under solvent-free conditions

(Chemical Equation Presented) An efficient and convenient method for the preparation of 4,6-diaryl-2(1H)-pyridones by the one-pot reaction of aromatic aldehydes, aromatic ketones and malononitrile, in the presence of sodium hydroxide under solvent-free co

An efficient and facile synthesis of 2-amino-4,6-diarylbenzene-1,3- dicarbonitrile and 1,2-dihydro-2-oxo-4,6-diarylpyridine-3-carbonitrile under solvent-free conditions

A one-pot three-component condensation of aromatic aldehyde, aromatic ketone, and malononitrile leading to an efficient synthesis of 2-amino-4,6-diarylbenzene-1,3-dicarbonitrile and 1,2-dihydro-2-oxo-4,6- diarylpyridine-3-carbonitrile has been carried out

A simple and convenient synthesis of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones under solvent-free microwave conditions

A rapid and efficient method for the preparation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones by the reaction between 1,3-diarylpropen-1-ones and cyanoacetamide using powdered potassium hydroxide under microwave irradiation is reported. Excellent yields and higher purity are obtained in this solvent free one pot synthesis as compared to conventional methods.

Synthesis of N-glycosylated pyridines as new antiviral agents

A series of 3-cyanopyridine glycosides have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells. Among the 3-cyanopyridine glycosides 6-(p- methylphenyl) and 6-(p-aminophenyl) were the most selective inhibitors of HIV replication.

Reactions of Malononitrile with Acetylenic Esters and Ketones

The addition of malononitrile to acetylenic esters and acetylenic ketones catalysed by sodium alkoxides leads to the formation of 3- and 5-cyano-2-pyridones, 2-cyano- and 2,6-dicyano-aniline derivatives, and other products.