80312-89-6Relevant academic research and scientific papers
A hand natural alkene propyl thiol carboxylic acid ester and its synthetic method
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Paragraph 0023; 0024; 0025; 0028; 0029; 0031, (2017/04/29)
The invention relates to a chiral allyl thiocarboxylate and its preparation method. The chemical structural formula of the chiral allyl thiocarboxylate is shown in the specification; and in the formula, R1 is selected from C1-C16 alkyl groups, C4-C10 heterocyclic groups containing N, O or S, or C4-C10 heteroaryl or alky groups containing N, O or S, and R2 is selected from C1-13 alky groups or aryl groups. The method comprises the following steps: carrying out a reaction on raw materials comprising potassium thiocarboxylate and an allylic carbonate compound in an organic solvent at -20-30DEG C under the action of an additive with an iridium complex generated by reacting [Ir(COD)Cl]2 with a ligand as a catalyst for 2-48h, recrystallizing, and carrying out thin layer chromatography, column chromatography or reduced pressure distillation to separate in order to obtain the chiral allyl thiocarboxylate. Compared with the prior art, the method has the advantages of easily available and highly active catalyst, mild conditions, wide application range of substrates, and the like.
A novel method for the synthesis of thioacetates using benzyltriethyl- ammonium tetrathiomolybdate and acetic anhydride
Nasir, Baig R. B.,Sai, Sudhir V.,Srinivasan, Chandrasekaran
experimental part, p. 2684 - 2688 (2009/04/16)
Herein we report a simple and efficient methodology for the synthesis of thioacetates using benzyltriethylammonium tetrathiomolybdate and acetic anhydride as the key reagents, starting from alkyl halides in a multistep, tandem reaction process. Its application in the synthesis of orthogonally protected cysteine and anomeric β-thioglycosides has also been demonstrated.
A NEW, HIGHLY EFFICIENT METHOD FOR THE CONVERSION OF ALCOHOLS TO THIOLESTERS AND THIOLS
Volante, R. P.
, p. 3119 - 3122 (2007/10/02)
Various alcohols were converted to their corresponing thiolacetates by treatment with triphenylphosphine and diisopropyl azodicarboxylate in the presence of thiolacetic acid.The overall conversion was both highly efficient (89-99percent yields) and stereoselective (99.5percent inversion).
