80357-08-0

Usage

Uses

Used in Organic Synthesis:
(1,1-dioxo-1H-1l6-benzo[d]isothiazol-3-ylsulfanyl)-acetonitrile is used as a reactive intermediate in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for versatile chemical transformations, making it a valuable component in the synthesis of specialty chemicals and pharmaceutical intermediates.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (1,1-dioxo-1H-1l6-benzo[d]isothiazol-3-ylsulfanyl)-acetonitrile is utilized as a building block for the development of pharmaceutical drugs. Its functional groups can be modified to create new drug candidates with potential therapeutic properties. (1,1-dioxo-1H-1l6-benzo[d]isothiazol-3-ylsulfanyl)-acetonitrile's reactivity and functional nature make it a promising candidate for the design of novel pharmaceutical agents.
Used in Chemical Research:
(1,1-dioxo-1H-1l6-benzo[d]isothiazol-3-ylsulfanyl)-acetonitrile is also used in chemical research to study the properties and reactions of complex organic molecules. Its unique structure provides opportunities for investigating new reaction pathways and understanding the fundamental principles of organic chemistry.
Used in Specialty Chemicals Production:
(1,1-dioxo-1H-1l6-benzo[d]isothiazol-3-ylsulfanyl)-acetonitrile is employed in the production of specialty chemicals, where its reactive and functional properties are harnessed to create high-value products for various industries, such as agrochemicals, dyes, and materials science.

Upstream product

• 107-14-2 chloroacetonitrile 
• 80357-05-7 1,2-benzisothiazol-3-(2H)-thione-1,1-dioxide nitranion sodium salt 
• 27148-03-4 thiosaccharine 
• 81-07-2 saccharin 

Downstream Products

• 59463-55-7 S-cyanomethyl thiobenzoate 

Relevant academic research and scientific papers

Pseudosaccharin amine derivatives: Synthesis and elastase inhibitory activity

Pseudosaccharin amines were synthesized from saccharin either by the reaction of pseudosaccharin chloride with amines, or via thiosaccharin which was treated with amines yielding thiosaccharinates, and their reaction with glacial acetic acid. This route gave lower yields than the first way. The synthesis of alkyl [(1,1-dioxo-benzo[d]isothiazol-3-yl)amino]alkanoates as possible Human Leukocyte Elastase (HLE) inhibitors was realized by the reaction between amino acid esters and pseudosaccharin chloride. Hydrolysis of the esters was possible under aqueous basic conditions. Selected compounds were screened for elastase inhibitory activity. Compounds 4k and 4m were found to be reversible inhibitors of HLE with Ki values of 45 μM and 60 μM.

An Odorless Preparative Method of Sulfides and Thiocarboxylic S-Esters Using 3-(Alkylthio)-1,2-benzisothiazole 1,1-Dioxide

It was found that sodium salt of 1,2-benzisothiazole-3(2H)-thione 1,1-dioxide (thiosaccharin) readily reacted with alkyl halide affording 3-(alkylthio)-1,2-benzisothiazole 1,1-dioxide (3).Treatment of 3 with piperidine produces the corresponding alkanethiol in situ quantitatively and subsequent treatment with various electrophiles gives the corresponding sulfides and thiocarboxylic S-esters in good yields.

SYNTHESIS AND REACTION OF 3-(ALKYLTHIO)-1,2-BENZISOTHIAZOLE 1,1-DIOXIDES AS AN ODORLESS CRYSTALLINE EQUIVALENT OF THIOLS

It was found that sodium salt of 1,2-benzisothiazol-3(2H)-thione 1,1-dioxide (thiosaccharin) readily reacted with alkyl halide affording 3-(alkylthio)-1,2-benzisothiazole 1,1-dioxide, which very smoothly produced the corresponding alkanethiol by the reaction with piperidine in almost quantitative yield.