803687-56-1

Upstream product

• 656-65-5 3-fluoro-4-bromophenylamine 
• 287944-16-5 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyran 
• 188975-30-6 5,6-dihydro-4-trifluoromethylsulfonyloxy-2H-pyran 
• 166758-23-2 1-(3-fluorophenyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane 
• 372-19-0 meta-fluoroaniline 

Downstream Products

• 803687-61-8 C-{1-[4-(3,6-dihydro-2H-pyran-4-yl)-3-fluoro-phenyl]-1H-[1,2,3]triazol-4-yl}-methylamine 

Relevant academic research and scientific papers

Pyridazine-3-carboxamide compound and preparation method and application thereof in medicine

The invention relates to a pyridazine-3-carboxamide compound suitable for inhibiting or regulating Janus kinase (JAK), especially tyrosine kinase 2 (TYK2), a preparation method of the pyridazine-3-carboxamide compound and an application of the pyridazine-3-carboxamide compound in medicine. Specifically, the invention relates to a compound represented by a general formula (I) and pharmaceutically acceptable salts thereof, a pharmaceutical composition containing the compound or the pharmaceutically acceptable salts thereof, and a method for treating and/or preventing Janus kinase-mediated related diseases, especially autoimmune diseases, inflammatory diseases and cancer by applying the compound or the pharmaceutically acceptable salts thereof, and a preparation method of the compound or thepharmaceutically acceptable salts thereof. Each substituent of the general formula (I) has the same definition as in the specification.

NOVEL ANTIINFECTIVE COMPOUNDS AND THEIR PHARMACEUTICAL COMPOSITIONS

The present invention provides novel triazole compounds of formula (I), their pharmaceutically acceptable salts and their pharmaceutical compositions, where all symbols are as defined in the specification

Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings

A compound of the formula (I): STR1 or pharmaceutical acceptable salts thereof wherein X is NR1, S(O)g, or O; R1 is H, C1-6 alkyl optionally substituted with one or more OH, CN, or halo, or R1 is --(CH2)h -- aryl, --COR1--1, --COOR1-2, --CO--(CH2)h --COR1--1, C1-6 alkyl sulfonyl, --SO2 --(CH2)h --aryl, or --(CO)i --Het; R2 is H, C1-6 alkyl, --(CH2)h --aryl, or halo; R3 and R4 are the same or different and are H or halo; R5 is H, C1-12 alkyl optionally substituted with one or more halo, C3-12 cycloalkyl, C1-6 alkoxy. The compounds are useful antimicrobial agents.