80427-23-2

Basic information

• Product Name: (2,5-dimethoxyphenyl)(4-methoxyphenyl)methanone
• CAS NO: 80427-23-2
• Molecular Formula: C₁₆H₁₆O₄
• Molecular Weight: 272.2958
• Mol File: 80427-23-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 444°C at 760 mmHg
• Flash Point: 197.9°C
• Density: 1.136g/cm³
• Vapor Pressure: 4.43E-08mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: (2,5-dimethoxyphenyl)(4-methoxyphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2,5-dimethoxyphenyl)(4-methoxyphenyl)methanone(80427-23-2)
• EPA Substance Registry System: (2,5-dimethoxyphenyl)(4-methoxyphenyl)methanone(80427-23-2)

Safety Data

• Hazardous Substances Data: 80427-23-2(Hazardous Substances Data)

Usage

General Description

(2,5-dimethoxyphenyl)(4-methoxyphenyl)methanone, also known as Dimethoxyphenyl Methanone, is a chemical compound with the formula C16H16O4. It is a white crystalline powder that is commonly used as a precursor in the synthesis of various organic compounds. (2,5-dimethoxyphenyl)(4-methoxyphenyl)methanone is often employed in the pharmaceutical industry for the production of medications and research chemicals. It is also used in the field of organic chemistry as a reagent in the synthesis of complex molecules. Additionally, (2,5-dimethoxyphenyl)(4-methoxyphenyl)methanone has been studied for its potential psychoactive properties, though it is not commonly used for this purpose. Overall, this compound has versatile applications in various industries, making it a valuable chemical in the field of organic synthesis.

Upstream product

• 2100-42-7 2-chloro-1,4-dimethoxybenzene 
• 146985-16-2 {2,5-(OMe)2-C₆H₃}ZnCl 
• 100-07-2 4-methoxy-benzoyl chloride 
• 150-78-7 1,4-dimethoxybezene 

Downstream Products

• 80427-40-3 2,4'-dihydroxy-5-methoxybenzophenone 
• 16762-04-2 2-hydroxy-4',5-dimethoxybenzophenone 

Relevant articles and documents

Expedient Preparation of Aryllithium and Arylzinc Reagents from Aryl Chlorides Using Lithium 4,4′-Di- tert -Butylbiphenylide and Zinc(II) Chloride

We report an efficient method for the preparation of aryllithium and zinc reagents from inexpensive and readily available aryl chlorides by using lithium 4,4′-di-tert-butylbiphenylide (LiDBB) as a lithiation reagent. The resulting organometallic reagents underwent subsequent reactions with a variety of electrophiles, such as an aldehydes, DMF, PhSSO2Ph, TsCN, an aryl halide, or an acid chloride (through Pd-catalyzed cross-coupling). Aryl chlorides bearing substituents, including methoxy, 3,4-methylenedioxy, fluoride, TMS, OTMS, NMe2, acetal, and ketal, were shown to be appropriate substrates. Interestingly, aryl chlorides containing a formyl group could also be used, provided that the formyl group was temporarily converted into an α-amino alkoxide by using the lithium amide of N,N,N′-trimethylethylenediamine (LiTMDA). The presence of a hydroxyl group was also tolerated when it was deprotonated with n-BuLi prior to the addition of LiDBB.

BeCl2 as a new highly selective reagent for dealkylation of aryl-methyl ethers

An efficient and simple method is introduced for the selective removal of methyl group from poly aryl-methyl ethers, in some important derivatives of benzophenones, xanthones, anthraquinones, aryl esters, benzamides and nitroanisoles with BeCl2.