80427-23-2

Usage

Uses

Used in Pharmaceutical Industry:
(2,5-dimethoxyphenyl)(4-methoxyphenyl)methanone is used as a precursor for the production of medications and research chemicals. Its versatile chemical structure allows for the synthesis of complex molecules, making it a valuable component in the development of new pharmaceuticals.
Used in Organic Chemistry:
(2,5-dimethoxyphenyl)(4-methoxyphenyl)methanone is used as a reagent in the synthesis of complex molecules. Its unique properties enable it to be used in various organic reactions, contributing to the advancement of organic chemistry.
Used in Psychoactive Research:
(2,5-dimethoxyphenyl)(4-methoxyphenyl)methanone has been studied for its potential psychoactive properties, although it is not commonly used for this purpose. Its exploration in this field may lead to new insights and applications in psychopharmacology.

Upstream product

• 146985-16-2 {2,5-(OMe)2-C₆H₃}ZnCl 
• 100-07-2 4-methoxy-benzoyl chloride 
• 2100-42-7 2-chloro-1,4-dimethoxybenzene 
• 150-78-7 1,4-dimethoxybezene 

Downstream Products

• 16762-04-2 2-hydroxy-4',5-dimethoxybenzophenone 
• 80427-40-3 2,4'-dihydroxy-5-methoxybenzophenone 

Relevant academic research and scientific papers

Expedient Preparation of Aryllithium and Arylzinc Reagents from Aryl Chlorides Using Lithium 4,4′-Di- tert -Butylbiphenylide and Zinc(II) Chloride

We report an efficient method for the preparation of aryllithium and zinc reagents from inexpensive and readily available aryl chlorides by using lithium 4,4′-di-tert-butylbiphenylide (LiDBB) as a lithiation reagent. The resulting organometallic reagents underwent subsequent reactions with a variety of electrophiles, such as an aldehydes, DMF, PhSSO2Ph, TsCN, an aryl halide, or an acid chloride (through Pd-catalyzed cross-coupling). Aryl chlorides bearing substituents, including methoxy, 3,4-methylenedioxy, fluoride, TMS, OTMS, NMe2, acetal, and ketal, were shown to be appropriate substrates. Interestingly, aryl chlorides containing a formyl group could also be used, provided that the formyl group was temporarily converted into an α-amino alkoxide by using the lithium amide of N,N,N′-trimethylethylenediamine (LiTMDA). The presence of a hydroxyl group was also tolerated when it was deprotonated with n-BuLi prior to the addition of LiDBB.

Phenyl benzisoxazoles as estrogenic agents

This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, and R3 are as defined in the specification, or a pharmaceutically acceptable salt thereof.

BeCl2 as a new highly selective reagent for dealkylation of aryl-methyl ethers

An efficient and simple method is introduced for the selective removal of methyl group from poly aryl-methyl ethers, in some important derivatives of benzophenones, xanthones, anthraquinones, aryl esters, benzamides and nitroanisoles with BeCl2.

Studies on the Friedel-Crafts Reaction. XVI, Preparation of Isomeric 2-Acyl- and 3-Acyl-4-methoxy Phenols

Acylation of 4-methoxy phenol according to Friedel and Crafts, as well as the rearrangement of its esters according to Fries lead always to 2-acyl-4-methoxy phenols or to their demethylated compounds.The unknown 3-acyl-4-methoxyphenols were prepared in two steps: First, the ester is acylated with the corresponding acyl chloride and SnCl4 in nitromethane.In the second step the resulting ketoesters are hydrolysed.This is a general method.The yields of meta-acylphenols are between 40 and 90percent.The isomeric 2-acyl-4-methoxyphenols which were partly unknown or accessible only in low yields have also been prepared for comparative spectral studies (UV, IR, NMR, MS) of ortho- and meta-acylphenols. - Keywords: Friedel-Crafts acylation; Fries rearrangement; Ketoesters; Spectral data