80428-00-8

Upstream product

• 54903-61-6 6-acetyl-3-methylbenzoxazolinone 
• 100-52-7 benzaldehyde 
• 83297-64-7 3-Methyl-6-[(E)-(3-phenyl-acryloyl)]-3H-benzooxazol-2-one 

Downstream Products

• 1207378-82-2 7,8-dimethoxy-1,10-dimethyl-11-phenyl-1,11-dihydro-2H-[1,3]oxazolo[4'.5':5,6]indeno[1.2-b]quinolin-2-one 
• 134541-24-5 7-dimethylamino-3-methyl-2-oxo-5-phenyl-2,3,5,6-tetrahydrocyclopentabenzoxazole hydrochloride 
• 134541-27-8 3-methyl-7-methylamino-2-oxo-5-phenyl-2,3,5,6-tetrahydrocyclopentabenzoxazole hydrochloride 
• 134541-23-4 7-amino-3-methyl-2-oxo-5-phenyl-2,3,5,6-tetrahydrocyclopentabenzoxazole hydrochloride 
• 134541-22-3 2,8-dioxo-3-methyl-5-phenyl-2,3,5,6,7,8-hexahydropyrido<4,3-f>benzoxazole 
• 134541-26-7 3-methyl-2-oxo-5-phenyl-2,3-dihydro-5H-cyclopentabenzoxazole 
• 134541-21-2 3-methyl-7-oximino-2-oxo-5-phenyl-2,3,5,6-tetrahydrocyclopentabenzoxazole 
• 134541-25-6 7-hydroxy-3-methyl-2-oxo-5-phenyl-2,3,5,6-tetrahydrocyclopentabenzoxazole 

Relevant academic research and scientific papers

Synthesis of 1,11-dihydro-2H-[1,3]oxazolo[4′,5′:5,6]indeno[1,2- b]quinolin-2-ones with potential topoisomerase I inhibitory activity

A series of 1,11-dihydro-2,11-[1,3]oxazolo[4′,5′:5,6]indeno[1, 2-b]quinolin-2-ones were prepared by means of Friedlaender condensations. The starting materials for the preparations were commercial substituted-2- aminoacetophenones and various 5,6-dihydro-2H-indeno[5,6-d][l,3]oxazole-2,7(3H)- diones that were synthesized from 2(3H)-benzoxazolones or their N-methyl analogues. Thieme Verlag Stuttgart.

Synthesis of 3-methyl-7-[2-(dimethylaminoethyl)oximino]-5-arylcyclopenta[f]benzoxaz olinones, potential ligands of the 5HT(1D) receptors

The synthesis of 3-methyl-7-[2-(dimethylaminoethyl)oximino]-5-arylcyclopenta[f]benzoxaz olinones, potential ligands of the 5HT(1D) receptors is described through a 4 step reaction strategy from 3-methyl-6-acetyl benzoxazolinone.

Condensation of 3-Methylbenzoxazolinone with α,β-Unsaturated Acids

The reaction between 3-methylbenzoxazolinone and some unsaturated acids in PPA leads to mixtures of compounds, depending on the acid: 6-crotonyl-(or cinnamoyl)-3-methylbenzoxazolinones, 2,3-dihydro-2,5-(or 2,7)dioxo-3-methylcyclopentabenzoxazoles and 6-(3-oxo-indanyl)-3-methylbenzoxazolinones.The structure of the products was established by 13C and 1H nmr spectroscopy and (or) by independent synthesis.Possible mechanisms of the reaction are discussed; when competition is possible as in the last step of the cyclization, the benzene ring shows a higher reactivity than the aromatic nucleus of the benzoxazolinone: the contrary is observed when the benzene ring is p-chloro-substituted.