80441-55-0Relevant articles and documents
Syntheses of siderophore-drug conjugates using a convergent thiol-maleimide system
Juarez-Hernandez, Ral E.,Miller, Patricia A.,Miller, Marvin J.
supporting information, p. 799 - 803 (2013/01/15)
Three siderophore-drug conjugates (sideromycins) were synthesized by preparation of a maleimide linked derivative of the siderophore desferrioxamine B and reacting the corresponding Ga3+-complex with freshly prepared thiol-containing antibiotics: loracarbef, ciprofloxacin, and nadifloxacin. The conjugates and their synthetic precursors were tested against a broad panel of bacteria and were found to display Gram-positive selective, growth inhibitory activity (μM), indicating that this approach is suitable for the convergent syntheses and screening of novel sideromycins.
Cyclic disulfides as functional mimics of the histone deacetylase inhibitor FK-228
Mays, Jared R.,Restituyo, José A.,Katzenberger, Rebeccah J.,Wassarman, David A.,Rajski, Scott R.
, p. 4579 - 4583 (2008/02/04)
FK-228 is a potent histone deacetylase (HDAC) inhibitor with tremendous therapeutic potential against a wide array of human cancers. We describe the development of analogs that share FK-228's novel mechanism of activation and HDAC inhibition.
FK228 ANALOGS AND METHODS OF MAKING AND USING THE SAME
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Page/Page column 6/7; 25-26, (2010/02/12)
The present invention provides FK228 analogs and methods of making and using the same. Such analogs are potent inhibitors of histone deacetylase and, in certain embodiments, are capable of specifically targeting cancerous cells and tissues. In preferred e
