80452-54-6Relevant academic research and scientific papers
Synthesis of the major metabolites of Tolvaptan
Wan, Wei Li,Wu, Jian Bo,Lei, Fan,Li, Xiao Long,Hai, Li,Wu, Yong
, p. 1343 - 1346 (2013/02/22)
Tolvaptan is a nonpeptide arginine vasopressin (AVP) V2-receptor antagonist and used in the treatment of heart failure, cirrhosis, syndrome of inappropriate antidiuretic hormone secretion or other high-volume capacity of hyponatremia. The metab
BENZOCONDENSED HEPTAATOMIC HETEROCYCLES AND THEIR DERIVATIVES. VII. SYNTHESIS OF BENZAZEPINES AND BENZAZEPINONES ANALOGUES OF KNOWN ANXIOLYTIC DRUGS
Rossi, Silvano,Micheli, Marcello,Giannotti, Michele,Salvatori, Americo,Peruzzi, Guidubaldo
, p. 365 - 370 (2007/10/02)
Two syntheses are described for a series of benzazepines structurally similar to known anxiolytic drugs.Some of the new molecules are active in the barbiturates-induced sleep potentiation test and possess a negligible acute toxicity.
