80459-31-0

Upstream product

• 90904-24-8 (S)-4-Octadecyloxymethyl-2-phenyl-[1,3]dioxolane 
• 80707-92-2 2-O-Benzyl-3-O-octadecyl-1-O-trityl-sn-glycerin 
• 10567-22-3 (R)-octadecylglycerol 
• 83526-53-8 (R)-1,2-Epoxy-3-(octadecyloxy)propan 
• 10585-86-1 1,2-Di-O-isopropyliden-3-O-octadecyl-sn-glycerin 
• 38270-72-3 dimethyl 2,3-O-benzylidene-L-tartrate 
• 197306-95-9 1-octadecyl-3-t-butyldimethylsilyl-D-glycerol 
• 112-89-0 1-Bromooctadecane 
• 1445389-91-2 C₄₂H₆₂O₅ 
• 100-39-0 benzyl bromide 
• 84379-60-2 2-O-benzyl-3,4-O-isopropylidene-1-O-octadecyl-L-threitol 
• 100-52-7 benzaldehyde 
• 84379-51-1 2-O-benzyl-L-threitol 
• 84379-53-3 2-O-benzyl-3,4-O-isopropylidene-L-threitol 

Downstream Products

• 80736-27-2 2-O-Benzyl-3-O-octadecyl-sn-glyceryl-1-phosphorylcholin 
• 80736-28-3 3-O-octadecyl sn-glycero(1)phosphocholine 
• 83526-72-1 3-O-Acetyl-1-O-octadecyl-sn-glycerin 
• 83526-75-4 (S)-1-O-octadecyl-3-acetylglycerol 
• 80707-96-6 Ro 15-4454 
• 105415-95-0 (S)-2-benzyloxy-3-octadecyloxypropyl 2-(N-methylpyrrolidinio)ethyl phosphate 
• 105415-94-9 (S)-2-benzyloxy-3-octadecyloxypropyl 2-(diethylmethylammonio)ethyl phosphate 
• 96022-72-9 2-O-Benzyl-3-O-octadecyl-1-O-<2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-β-D-glucopyranosyl>-rac-glycerin 

Relevant academic research and scientific papers

PHOSPHOLIPID COMPOUNDS AND USES THEREOF

Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed (Formula (I)).

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.

Chiral PAF agonists: Synthesis, theoretical analysis of their stereoelectronic properties and structure activity relationships

A series of chiral PAF agonists were synthesized. Modifications at the PAF structure were undertaken as far as the C2 substituents and the onium head groups are concerned. In parallel, molecular modelling studies including a MOPAC geometry optimization and the analysis of the electrostatic potential were performed on the newly synthesized and on already known PAF agonists, in order to gain a better insight into the stereoelectronic features required for interaction with the PAF receptor.

Stereoselective Synthesis of Long-chain 1-O-(β-D-Maltosyl)-3-O-alkyl-sn-glycerols (Alkyl Glyceryl Ether Lysoglycolipids)

The synthesis of long-chain 2-O-benzyl-3-O-alkyl-sn-glycerols 5 was improved, making these compounds easily accessible for glycosylation experiments.Glycosylation with α-acetobromomaltose following a modified Koenings-Knorr procedure after removal of the protective groups yielded the title compound 9 in good yields.These compounds represent examples of alkyl glyceryl ether lysoglycolipids.Some properties of these amphiphilic compounds with a nonionic carbohydrate head-group differ not much (critical micell concentration, hemolytic activity), other properties differ very much (antitumor efficiency) from the properties of the analogous compounds with a zwitterionic phosphorylcholine head-group.