80459-44-5Relevant academic research and scientific papers
Benign Arylations of Dimethyl Itaconate via Heck–Matsuda Reaction Utilizing in-Situ Generated Palladium on Aluminum Oxide
Matelien?, Lauryna,Knaup, Jan,von Horsten, Frank,Gu, Xiaoting,Brunner, Heiko
, p. 127 - 135 (2020)
In situ generated palladium on aluminum oxide provides an active and efficient catalytic system for the preparation of arylmethylidene succinates using the Heck–Matsuda reaction. Beside the monoarylation the first examples of the biarylation of these mono
Phosphine-Catalyzed Cross-Coupling of Benzyl Halides and Fumarates
Yan, Tingting,Babu, Kaki Raveendra,Wu, Yong,Li, Yang,Tang, Yuhai,Xu, Silong
supporting information, p. 4570 - 4574 (2021/06/28)
A phosphine-catalyzed olefinic cross-coupling between benzyl halides and fumarates is described, which affords trisubstituted alkenes in good yields and excellent E-selectivity under metal-free conditions. Mechanistic studies suggest a catalytic cycle involving phosphorus ylide formation, Michael addition, water-assisted hydrogen transfer, and phosphine elimination.
NOVEL BUTADIENE DERIVATIVES, PROCESS FOR PREPARATION OF THE SAME AND INTERMEDIATES FOR THE SYNTHESIS THEREOF
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Page 8, (2010/11/30)
A butadiene derivative having an excellent inhibitory activity on the PAI-1, which is represented by the general formula [I]: wherein R1 is a hydrogen atom or a lower alkyl group, R2 is a lower alkyl group, R3 is a lower alkoxy group, R4 is a hydrogen atom or a lower alkyl group, R5 is a lower alkyl group, or a pharmaceutically acceptable salt thereof, a process a process for preparing the same and an intermediate thereof.
