80463-23-6

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-[4-(1,3-dioxolan-2-yl)phenyl]is used as an intermediate in the synthesis of various pharmaceutical compounds for its ability to contribute to the development of new drugs and improve existing ones.
Used in Organic Synthesis:
In the field of organic synthesis, Ethanone, 1-[4-(1,3-dioxolan-2-yl)phenyl]is used as a key building block for creating a wide range of organic molecules, including fragrances, dyes, and other specialty chemicals.
Used in Chemical Production:
Ethanone, 1-[4-(1,3-dioxolan-2-yl)phenyl]is employed as a precursor in the production of various chemicals, highlighting its importance in the chemical industry for creating new and innovative products.

Upstream product

• 80463-21-4 4-(1-hydroxyethyl)benzaldehyde 
• 75633-63-5 4-(hydroxymethyl)acetophenone 
• 66739-89-7 4-(1,3-dioxolan-2-yl)benzonitrile 
• 676-58-4 methylmagnesium chloride 
• 591247-28-8 1-[4'-(1,3-dioxolan-2''-yl)phenyl]-4-(3''',5'''-dimethoxyphenyl)butan-1-one 
• 3457-45-2 p-formylacetophenone 
• 107-21-1 ethylene glycol 

Downstream Products

• 951656-07-8 α-bromo-4-formylacetophenone 
• 3457-45-2 p-formylacetophenone 
• 80463-21-4 4-(1-hydroxyethyl)benzaldehyde 

Relevant academic research and scientific papers

BTK INHIBITOR

Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).

Highly efficient and chemoselective acetalization and thioacetalization of aldehydes catalyzed by propylphosphonic anhydride (T3P) at room temperature

Propylphosphonic anhydride (T3P), a low toxic peptide coupling agent, has been demonstrated to be an efficient catalyst for the chemoselective acetalization and thioacetalization of aldehydes in the presence of ketones. Cyclic and acyclic acetals of diverse aldehydes were obtained in good to excellent yields at room temperature in the presence of a catalytic amount of T3P.

Acetalization of carbonyl compounds catalyzed by bismuth triflate under solvent-free conditions

Carbonyl compounds were converted to the corresponding 1,3-dioxolanes and 1,3-dioxanes with ethylene glycol and 1,3-propandiol in the presence of bismuth triflate under solvent-free conditions. In addition, high chemoselective protection of aldehydes in the presence of ketones has been achieved.

FUSED BICYCLIC IMIDAZOLES

Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.

FUSED IMIDAZOLES FOR CANCER TREATMENT

Compounds of Formula (I), a tautomer or stereoisomer thereof, or a salt thereof,wherein ring B and the imidazole to which it is fused, R4, R6 and R7 have the meanings as given in the description and the claims, are effective inhibi tors of the Pi3K/Akt pathway.

Origin of selectivity in the antibody 20F10-catalyzed Yang cyclization

The first antibody-catalyzed Yang (Norrish type II) cyclization has been achieved with antibodies that were elicited against cis- and trans-2,3-diaryloxetanes. The photocyclization of 1,4-diarylbutan-1-one produced a single stereoisomer of cis-1,2-diarylc

ALUMINA AS AN VERSATILE CATALYST FOR THE SELECTIVE ACETALIZATION OF ALDEHYDES

Alumina was found to be an effective and convenient catalyst for acetalization of aldehydes to the corresponding 1,3-dioxoranes and 1,3-dioxanes.It can be used for selective protection of only formyl group of ketoaldehydes.

APPLICATION OF THE COMBINATION OF SODIUM BISULFITE AS A PROTECTIVE REAGENT AND SOLID SUPPORTS IN THE SELECTIVE REDUCTION OF 4-ACETYLBENZALDEHYDE WITH DIBORANE

4-Acetylbenzaldehyde (2) has been selectively reduced by using a combination of protective group and solid supports.The formyl group of 2 was protected by addition of sodium bisulfite.The adduct, supported on silica gel, was then selectively reduced to 4-