80483-84-7Relevant academic research and scientific papers
The enantioselective trifluoromethylation of aromatic aldehydes by quaternary ammonium bromide and (IPr)CuF at low catalyst loading
Wu, Shaoxiang,Guo, Jiyi,Sohail, Muhammad,Cao, Chengyao,Chen, Fu-Xue
, p. 19 - 29 (2013/04/23)
A general catalytic enantioselective trifluoromethylation of aromatic aldehydes using (IPr)CuF and quinidine-derived quaternary ammonium salt as catalysts has been developed. A wide range of aromatic aldehydes are converted to the corresponding products in up to 92% yield and 81% ee at 2 mol% of catalyst loading.
Reduction by a Model of NAD(P)H. 33. Steric and Electronic Effects on Asymmetric Reduction of 2-Acylpyridines
Ohno, Atsuyoshi,Nakai, Jun-ichi,Nakamura, Kaoru,Goto, Takehiko,Oka, Shinzaburo
, p. 3482 - 3485 (2007/10/02)
Series of alkyl and fluorinated alkyl 2-pyridynyl ketones have been reduced by a chiral NAD(P)H-model (Me2PNPH) in the presence of magnesium ion in acetonitrile.Optical yield decreases in the order of substituent: CH3 > C2H5 > C(CH3)3 > CH(CH3)2 and CH3 > CH2F > CHF2 > CF3.The results have been interpreted in terms of conformation of the substrates for alkyl 2-pyridynyl ketones and of electronic competitional effect between two substituents for fluorinated alkyl 2-pyridynyl ketones.Magnesium ion freezes intermolecular arrangement at the transition state of the reduction.
