805246-33-7Relevant academic research and scientific papers
Heterocyclic inhibitors of AChE acylation and peripheral sites
Bolognesi, Maria Laura,Andrisano, Vincenza,Bartolini, Manuela,Cavalli, Andrea,Minarini, Anna,Recanatini, Maurizio,Rosini, Michela,Tumiatti, Vincenzo,Melchiorre, Carlo
, p. 465 - 473 (2005)
Notwithstanding the criticism to the so called "cholinergic hypothesis", the therapeutic strategies for the treatment of Alzheimer's disease (AD) have been mainly centered on the restoration of cholinergic functionality and, until the last year, the only
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues
Bolognesi, Maria Laura,Bartolini, Manuela,Cavalli, Andrea,Andrisano, Vincenza,Rosini, Michela,Minarini, Anna,Melchiorre, Carlo
, p. 5945 - 5952 (2007/10/03)
Rivastigmine (1), an acetylcholinesterase (AChE) inhibitor approved in 2000 for the treatment of Alzheimer disease, bears a carbamate moiety in its structure, which is able to react covalently with the active site of the enzyme. Kinetic and structural stu
