80526-53-0

Basic information

• Product Name: 2-cyclohexylidene-2-(4-methoxyphenyl)acetonitrile
• Synonyms: 2-cyclohexylidene-2-(4-methoxyphenyl)acetonitrile
• CAS NO: 80526-53-0
• Molecular Weight: 227.306
• Mol File: 80526-53-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-cyclohexylidene-2-(4-methoxyphenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyclohexylidene-2-(4-methoxyphenyl)acetonitrile(80526-53-0)
• EPA Substance Registry System: 2-cyclohexylidene-2-(4-methoxyphenyl)acetonitrile(80526-53-0)

Safety Data

• Hazardous Substances Data: 80526-53-0(Hazardous Substances Data)

Upstream product

• 104-47-2 p-methoxybenzylnitrile 
• 108-93-0 cyclohexanol 
• 108-94-1 cyclohexanone 
• 141-52-6 sodium ethanolate 

Downstream Products

• 469905-08-6 2-(4-methoxy-phenyl)-1-oxa-spiro[2.5]octane-2-carbonitrile 

Relevant articles and documents

Pyrenedione-Catalyzed α-Olefination of Nitriles under Visible-Light Photoredox Conditions

Herein, we report a combination of pyrenedione (PD) and KOtBu to achieve facile alcohol dehydrogenation under visible-light excitation, where aerobic oxygen is utilized as the terminal oxidant. The resulting carbonyl compound can be easily converted to vinyl nitriles in a single-pot reaction, at 60 °C in 6-8 h. This environmentally benign, organocatalytic approach has distinct advantages over transition-metal-catalyzed α-olefination of nitriles, which often operate at a significantly higher temperature for an extended reaction time.

Preparation method of venlafaxine impurities

The invention discloses a preparation method of venlafaxine impurities, which relates to the technical field of organic synthesis of medicines, the method comprises the following steps: carrying out acondensation reaction on p-methoxyphenylacetonitrile an

Novel intermediate and processes for its preparation and conversion into a pharmacologically-active agent

Processes for the preparation of Venlafaxine (IX) via the novel epoxy-nitrile intermediate (I), which when subjected to hydrogenation forms compound (X), and may subsequently be reduced to yield the desired product (IX). The epoxy-nitrile intermediate (I) itself may be synthesised via various alternative reaction strategies, from a range of starting materials. E.g. 4-methoxy-benzaldehyde (VI), upon treatment with cyclohexyl magnesium bromide yields compound (V). This in turn may be oxidised to yield compound (III), which forms compound (II) on treatment with an (x-keto-halogenation agent. Cyanation of compound (II), then yields the desired epoxy nitrile intermediate (I), from which Venlafaxine (IX) may be synthesised.