80536-46-5

Basic information

• Product Name: Isoxazole, 3-methyl-5-pentyl- (9CI)
• Synonyms: Isoxazole, 3-methyl-5-pentyl- (9CI)
• CAS NO: 80536-46-5
• Molecular Formula: C₉H₁₅NO
• Molecular Weight: 153.2215
• Product Categories: OXAZOLE
• Mol File: 80536-46-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Isoxazole, 3-methyl-5-pentyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Isoxazole, 3-methyl-5-pentyl- (9CI)(80536-46-5)
• EPA Substance Registry System: Isoxazole, 3-methyl-5-pentyl- (9CI)(80536-46-5)

Safety Data

• Hazardous Substances Data: 80536-46-5(Hazardous Substances Data)

Upstream product

• 542-69-8 1-iodo-butane 
• 62759-26-6 ((3-methylisoxazol-5-yl)methyl)lithium 
• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 2816-57-1 2,6-dimethylcyclohexanone 
• 10557-85-4 4-iodo-3,5-dimethylisoxazole 
• 109-72-8 n-butyllithium 

Downstream Products

• 94775-22-1 3-Methyl-5-pentyl-1-phenyl-1H-pyrazole 
• 80536-42-1 2-(5-Pentyl-isoxazol-3-yl)-1-phenyl-ethanol 
• 80536-40-9 1-(5-Pentyl-isoxazol-3-ylmethyl)-cyclohexanol 

Relevant articles and documents

A convenient procedure for transformation of tertiary cyclopropanols into 5-substituted isoxazoles

Tertiary cyclopropanols, when treated with an excess of amyl nitrite at room temperature, are smoothly converted into dimeric β-nitrosoketones. Heating the methanolic solutions of the latter under reflux gives 5-substituted isoxazoles in good yields. Geor

PREPARATION OF 6-(3,5-DIMETHYLISOXAZOL-4-YL)-6-OXOHEXANOIC ACIDS VIA 3,5-DIMETHYLISOXAZOL-4-YLMAGNESIUM IODIDE OR 3,5-DIMETHYLISOXAZOL-4-YLLITHIUM

3,5-Dimethylisoxazol-4-ylmagnesium iodide 1 or 3,5-dimethylisoxazol-4-yllithium 3 react with cyclohexanones 2a-c to give 4-(methylcyclohexen-1-yl)-3,5-dimethylisoxazoles 4a-c which in turn gave the title acids by oxidation.

ISOXAZOLES AS 4b-DIKETONE SYNTHONS-SELECTIVE ANION FORMATION ON 3,5-DIALKYLISOXAZOLES

3,5-Dimethylisoxazole can be metalated and alkylated regiospecifically.Alkylation occurs first on the 5-methyl group, and a second alkylation occurs on the 3-methyl group.This method permits specific synthesis of disubstituted isoxazoles, and of the corresponding β-diketones.