80537-07-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid is used as a potential candidate for the development of new drugs due to its anti-inflammatory, antifibrotic, and antioxidant properties. It may be employed for the treatment of inflammatory and fibrotic diseases.
Used in Medicinal Chemistry Research:
2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid is used as an interesting target for further research and development in medicinal chemistry, given its unique structure and properties.

Upstream product

• 127717-17-3 methyl 2-phenylpyrazolo<1,5-a>pyridine-3-carboxylate 
• 4891-38-7 phenylpropynoic acid methyl ester 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 51065-76-0 ethyl 2-phenylpyrazolo<1,5-a>pyridine-3-carboxylate 

Downstream Products

• 56983-95-0 2-phenylpyrazolo[1,5-a]pyridine 

Relevant academic research and scientific papers

PYRAZOLE AND IMIDAZOLE DERIVATIVES, COMPOSITIONS AND METHODS AS OREXIN ANTAGONISTS

The present invention is directed to substituted Pyrazole and Imidazole derivatives of compounds that are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which

Development of Structurally Diverse N-Heterocyclic Carbene Ligands via Palladium-Copper-Catalyzed Decarboxylative Arylation of Pyrazolo[1,5-a]pyridine-3-carboxylic Acid

A series of fused non-classical normal N-heterocyclic carbenes, Pyrpy-NHC precursors derived from pyrazolo[1,5-a]pyridines, has been prepared using palladium-copper-catalyzed decarboxylative arylation of pyrazolo[1,5-a]pyridine-3-carboxylic acid. Air-stable palladium and rhodium complexes of these ligands have been synthesized via mild transmetallation of Ag-Pyrpy-NHC. The structural properties of Rh(Pyrpy-NHC)(COD)Cl complexes were determined via X-ray analysis. The measurement of the CO stretching frequencies of dicarbonyl Rh-Pyrpy-NHC complexes revealed that the electron donating strength of Pyrpy-NHC could be tuned by varying the substituents of the aryl group. A catalytic study of the Pd-Pyrpy-NHC complexes revealed promising activity in the Suzuki–Miyaura reaction under ambient atmospheric conditions. (Figure presented.).

PYRAZOLOPYRIDINE DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF

A pyrazolopyridine derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof exhibits a strong EP1 receptor antagonistic effect. Thus, the derivative or the pharmacologically acceptable salt is useful as

1,3-Dipolar Addition of Pyridine N-Imine to Acetylenes and the Use of C-13 NMR in Several Structural Assignments

Addition of pyridine-N-imine to a variety of acetylenic mono- (Scheme I) and di- (Scheme II) carboxylic ester dipolarophiles was carried out.Several of the 3-azapyrrocoline esters obtained were further converted into acids, amides and hydrazides as shown in Schemes I and II.