80554-58-1

Usage

Uses

Used in Pharmaceutical Industry:
Schinifoline is used as an antitumor agent for its demonstrated inhibitory effects on the growth of several cancer cell lines, making it a potential candidate for cancer treatment.
Used in Anti-inflammatory Applications:
Schinifoline is utilized as an anti-inflammatory agent due to its ability to inhibit the release of inflammatory mediators and suppress the activation of inflammatory pathways, which can be beneficial in managing inflammatory conditions.
Used in Antioxidant Therapies:
Schinifoline is employed as an antioxidant, leveraging its properties to potentially protect against oxidative stress and related conditions, offering therapeutic benefits in various medical applications. Further research is essential to fully explore and understand the potential of schinifoline for drug development and medical use.

InChI:InChI=1/C17H23NO/c1-3-4-5-6-7-10-14-13-17(19)15-11-8-9-12-16(15)18(14)2/h8-9,11-13H,3-7,10H2,1-2H3

Upstream product

• 40522-46-1 2-heptyl-quinolin-4(1H)-one 
• 74-88-4 methyl iodide 
• 62-53-3 aniline 
• 111-64-8 n-octanoic acid chloride 
• 13283-92-6 β-ketodecanoic acid 
• 524-14-1 S-(hydrogen malonyl)coenzyme A 
• 22348-96-5 methyl 3-oxodecanoate 
• 66696-81-9 5-(1-hydroxyoctylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 77-78-1 dimethyl sulfate 
• 67342-98-7 2-acetyl-3-oxo-decanoic acid ethyl ester 
• 13195-66-9 ethyl 3-oxodecanoate 

Relevant academic research and scientific papers

Synthesis and biological activity of methylated derivatives of the Pseudomonas metabolites HHQ, HQNO and PQS

Selectively methylated analogues of naturally occurring 2-heptyl-4(1H)-quinolones, which are alkaloids common within the Rutaceae family and moreover are associated with quorum sensing and virulence of the human pathogen Pseudomonas aeruginosa, have been prepared. While the synthesis by direct methylation was successful for 3-unsubstituted 2-heptyl-4(1H)-quinolones, methylated derivatives of the Pseudomonas quinolone signal (PQS) were synthesized from 3-iodinated quinolones by methylation and iodine–metal exchange/oxidation. The two N- and O-methylated derivatives of the PQS showed strong quorum sensing activity comparable to that of PQS itself. Staphylococcus aureus, another pathogenic bacterium often co-occurring with P. aeruginosa especially in the lung of cystic fibrosis patients, was inhibited in planktonic growth and cellular respiration by the 4-O-methylated derivatives of HQNO and HHQ, respectively.

Synthesis of Unnatural 2-Substituted Quinolones and 1,3-Diketones by a Member of Type III Polyketide Synthases from Huperzia serrata

A curcuminoids, benzalacetone-, and quinolone-producing type III polyketide synthase (HsPKS3) from Huperzia serrata uniquely catalyzes the formation of unnatural 2-substituted quinolones and 1,3-diketones via head-to-head condensation of two completely different substrates. The broad range of substrate tolerance of HsPKS3 facilitates accessing structurally diverse 2-substituted quinolones and 1,3-diketones.